Cyclic Voltammetric Studies of Biologically Active Azomethine 2′-Hydroxyacetophenone Sulfamethoxazole

The cyclic voltammetric behavior of newly synthesized biologically active azomethine 2'-hydroxyacetophenone sulfamethoxazole (2'-HyAcPhSM) was examined at glassy carbon electrode in acetonitrile, acetone, methanol and DMF solvents using phosphate buffer and Britton-Robinson (BR) buffer. The effect of solvents, buffers, sweep rates and pH were calculated on peak potential and peak current. The cyclic voltammograms of 2'-HyAcPhSM exhibited two electronic, irreversible and diffusion-controlled single cathodic peak within the entire pH range which is attributed to the reduction of the azomethine group (-CH=N-) to amine group (-CH2-NH-). The biological activity of synthesized 2'-HyAcPhSM compound were carried out against various bacteria and fungi.