SYNTHETIC LETHALITY IN P53 MUTATED B-CELL MALIGNANCIES: CHK-1 INHIBITION AND DNA-PK INHIBITION EFFECT IN CELL LINES AND PRIMARY CLL CELLS

被引：0
|
作者：
Zemanova, J. [1 ]
Sebejova, L. [1 ]
Paruch, K. [2 ]
Hylse, O. [2 ]
Pospisilova, S. [1 ]
Mayer, J. [3 ]
Trbusek, M. [1 ]
机构：
[1] FN St Anna, Cent European Inst Technol MU, Brno, Czech Republic
[2] FN St Anna, Int Clin Res Ctr, Brno, Czech Republic
[3] FN Brno, Dept Internal Med, Brno, Czech Republic
来源：
HAEMATOLOGICA | 2013年 / 98卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
P971
引用
收藏
页码：402 / 402
页数：1
相关论文
共 50 条
  • [31] PI3K/AKT Mediated p53 Down-Regulation Participates in CpG DNA Inhibition of Spontaneous B Cell Apoptosis
    Zhou, Yongxin
    Zhen, Huiling
    Mei, Yunqing
    Wang, Yongwu
    Feng, Jing
    Xu, Shuchang
    Fu, Xiaoying
    CELLULAR & MOLECULAR IMMUNOLOGY, 2009, 6 (03) : 175 - 180
  • [32] SYK Inhibition Disrupts the Cross-Talk Between B-Cell Activation Factor (BAFF) and B-Cell Receptor (BCR) and Thereby Antagonizes Mcl-1 in Chronic Lymphocytic Leukemia (CLL) B-Cells
    Paiva, Cody
    Rowland, Taylor
    Danilova, Olga
    Sreekantham, Bhargava
    Spurgeon, Stephen E.
    Danilov, Alexey V.
    BLOOD, 2016, 128 (22)
  • [33] AKT/mTORC2 Inhibition Activates FOXO1 Function in CLL Cells Reducing B-Cell Receptor-Mediated Survival
    Cosimo, Emilio
    Tarafdar, Anuradha
    Moles, Michael W.
    Holroyd, Ailsa K.
    Malik, Natasha
    Catherwood, Mark A.
    Hay, Jodie
    Dunn, Karen M.
    Macdonald, Alanm.
    Guichard, SylvieM.
    O'Rourke, Declan
    Leach, Michael T.
    Sansom, Owen J.
    Cosulich, Sabina C.
    McCaig, Alison M.
    Michie, Alison M.
    CLINICAL CANCER RESEARCH, 2019, 25 (05) : 1574 - 1587
  • [34] Inhibition of p53 by Adenovirus Type 12 E1B-55K Deregulates Cell Cycle Control and Sensitizes Tumor Cells to Genotoxic Agents
    Li, Qiang
    Zhao, Lisa Y.
    Zheng, Zhi
    Yang, Heng
    Santiago, Aleixo
    Liao, Daiqing
    JOURNAL OF VIROLOGY, 2011, 85 (16) : 7976 - 7988
  • [35] Loss of p53 expression in cancer cells alters cell cycle response after inhibition o f exportin-1 but does not prevent cell death
    Marcus, Joshua M.
    Burke, Russell T.
    Doak, Andrea E.
    Park, Soyeon
    Orth, James D.
    CELL CYCLE, 2018, 17 (11) : 1329 - 1344
  • [36] ELAS1-mediated inhibition of the cyclin G1–B'γ interaction promotes cancer cell apoptosis via stabilization and activation of p53
    S Ohno
    Y Naito
    S Mukai
    N Yabuta
    H Nojima
    Oncogene, 2015, 34 : 5983 - 5996
  • [37] ELAS1-mediated inhibition of the cyclin G1-B′γ interaction promotes cancer cell apoptosis via stabilization and activation of p53
    Ohno, S.
    Naito, Y.
    Mukai, S.
    Yabuta, N.
    Nojima, H.
    ONCOGENE, 2015, 34 (49) : 5983 - 5996
  • [38] Aflatoxin B-1-induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines
    Mace, K
    Aguilar, F
    Wang, JS
    Vautravers, P
    GomezLechon, M
    Gonzalez, FJ
    Groopman, J
    Harris, CC
    Pfeifer, AMA
    CARCINOGENESIS, 1997, 18 (07) : 1291 - 1297
  • [39] CHK1/2 INHIBITION RESTORES THE ANTIPROLIFERATIVE EFFECT OF THE IMMUNOCONJUGATE INOTUZUMAB OZOGAMICIN (CMC-544) ON CD22-POSITIVE CELLS EXPRESSING MUTANT P53
    Massimino, M.
    Tirro, E.
    Fidilio, A.
    Chiarenza, A.
    Palumbo, G.
    Romano, A.
    Manzella, L.
    Di Raimondo, F.
    Stagno, F.
    Vigneri, P.
    HAEMATOLOGICA, 2016, 101 : S88 - S89
  • [40] CONCOMITANT DUAL ABLATION OF BLIMP1 AND P53 IN B-CELLS AS A NOVEL IN VIVO MODEL FOR HIGH-GRADE B-CELL LYMPHOMA
    Sacco, A.
    Kawano, Y.
    Moschetta, M.
    Park, J.
    Zavidij, O.
    Huynh, D.
    Reagan, M.
    Mishima, Y.
    Morgan, E.
    Takagi, S.
    Manier, S.
    Rossi, G.
    Imberti, L.
    Wong, K.
    Carrasco, R.
    Shipp, M.
    Ghobrial, I.
    Roccaro, A.
    HAEMATOLOGICA, 2017, 102 : 557 - 557
12345