A garlic oil-based organo-hydrogel for use in pH-sensitive drug release

被引：15

作者：

Alpaslan, Duygu ^{[1
]}

Olak, Tulu ^{[1
]}

Turan, Abdullah ^{[2
]}

Ersen Dudu, Tuba ^{[1
]}

Aktas, Nahit ^{[1
,3
]}

机构：

[1] Van Yuzuncu Yil Univ, Engn Fac, Dept Chem Engn, TR-65080 Van, Turkey

[2] Van Yuzuncu Yil Univ, Sci Fac, Dept Mol Biol & Genet, TR-65080 Van, Turkey

[3] Kyrgyz Turkish Manas Univ, Dept Chem Engn, Fac Engn, Bishkek, Kyrgyzstan

来源：

CHEMICAL PAPERS | 2021年 / 75卷 / 11期

关键词：

Organo-hydrogel; Agar; Garlic oil; Ceftriaxone; Carboplatin; DELIVERY; SOLVENT; CONSTITUENTS; CARBOPLATIN; SURVIVAL; EFFICACY; IMMUNITY; AGAR;

D O I：

10.1007/s11696-021-01760-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study, six different organo-hydrogels containing agar-glycerol (AG)-based garlic oil (GO) were synthesized using two different crosslinkers (N,N, methylenebisacrylamide (MBA), glutaraldehyde (GA)) to ensure the controlled release of ceftriaxone (Ce) and carboplatin (Cp). Synthesized organo-hydrogels were characterized by FT-IR. Afterward, swelling behaviors were investigated in DI, tap water, ethanol, acetone, ethanol/DI water (1:1), acetone/DI water (1:1) and gasoline environments and different pH. As a result of hemolysis, blood clotting and antioxidant analysis, organo-hydrogels have been shown to have blood compatibility and antioxidant properties. Ce and Cp release properties of the prepared organo-hydrogels were also determined. The highest Ce release rate was obtained to be 37.8% for p (AG-g-GO)(3) at pH 8.0 after 7 days. However, the highest Cp release rate was found to be 95.4% for p (AG-g-GO)(3) at pH 7.4 after 1 day.

引用

页码：5759 / 5772

页数：14

共 50 条

[31] Microfluidic synthesis of pH-sensitive multiamine hydrogel microparticles and release characterization of anticancer drug of doxorubicin (Dox)
Kim, Dae Il
Zhang, Yan
Kim, Hyung Hoon
Jeon, Hyeong Jin
Kim, Gyoo-Cheon
Go, Jeung Sang
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2014, 24 (05) : 464 - 468
[32] New amphiphilic and pH-sensitive hydrogel for controlled release of a model poorly water-soluble drug
Colinet, I.
Dulong, V.
Mocanu, G.
Picton, L.
Le Cerf, D.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2009, 73 (03) : 345 - 350
[33] A pH-sensitive poly(2-(acryloyloxy) propanoic acid) hydrogel and its drug release behaviors
Deng, Kuilin
Huang, Chunyuan
Ren, Xiaobo
Gou, Yubo
Zhong, Haibin
Zhang, Pengfei
Jiang, Chunyan
2011 INTERNATIONAL CONFERENCE ON FUZZY SYSTEMS AND NEURAL COMPUTING (FSNC 2011), VOL III, 2011, : 421 - 424
[34] A Ph-Sensitive Poly(2-(Acryloyloxy) Propanoic Acid) Hydrogel and its Drug Release Behaviors
Deng, Kuilin
Huang, Chunyuan
Ren, Xiaobo
Gou, Yubo
Zhong, Haibin
Zhang, Pengfei
Jiang, Chunyan
FUTURE MATERIAL RESEARCH AND INDUSTRY APPLICATION, PTS 1 AND 2, 2012, 455-456 : 901 - 906
[35] A pH-SENSITIVE HYDROGEL-BASED SMART SWITCH FOR GI-TRACT PAYLOAD RELEASE
Jiang, Hongjie
Yu, Wuyang
Zhou, Jiawei
Ziaie, Babak
30TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2017), 2017, : 510 - 513
[36] A pH-Sensitive Injectable Nanoparticle Composite Hydrogel for Anticancer Drug Delivery
Ye, Yuanfeng
Hu, Xiaohong
JOURNAL OF NANOMATERIALS, 2016, 2016
[37] Characterization, Formation Mechanisms, and pH-Sensitive Drug Release Behavior
Piao, Yongzhe
Chen, Biqiong
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 2015, 53 (05) : 356 - 367
[38] Synthesis and characterization of a novel pH-sensitive complex for drug release
Xu Dongying
Li Guangji
Liao Zhengfu
Chen Xudong
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION, 2010, 25 (01): : 24 - 27
[39] Synthesis and Characterization of a Novel pH-sensitive Complex for Drug Release
许东颖
李光吉
Journal of Wuhan University of Technology(Materials Science), 2010, (01) : 24 - 27
[40] Morphology and drug release of pH-sensitive microspheres containing flavonoids
Scarfato, Paola
Elvira, Avallone
Pio, Iannelli
Rita, Aquino
Domenico, Acierno
IVTH INTERNATIONAL CONFERENCE ON TIMES OF POLYMERS (TOP) AND COMPOSITES, 2008, 1042 : 99 - +

← 1 2 3 4 5 →