Synthesis and characterization of a novel pH-sensitive complex for drug release

被引：7

作者：

Xu Dongying ^{[1
]}

Li Guangji ^{[1
]}

Liao Zhengfu ^{[2
]}

Chen Xudong ^{[3
]}

机构：

[1] S China Univ Technol, Dept Polymer Sci & Engn, Guangzhou 510640, Peoples R China

[2] Guangdong Univ Technol, Fac Mat & Energy, Guangzhou 510006, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

来源：

JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION | 2010年 / 25卷 / 01期

基金：

中国国家自然科学基金;

关键词：

konjac glucomannan; pH-sensitivity; drug release; KONJAC GLUCOMANNAN; ACRYLIC-ACID; HYDROGELS; DELIVERY; CELLULOSE; BEHAVIOR;

D O I：

10.1007/s11595-010-1024-9

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A novel pH-sensitive complex was prepared by using oxidized konjac glucomannan and 4-aminosalicylic acid (4-ASA) through glutaraldehyde as a cross-linking agent. The product was characterized by FTIR and C-13 NMR spectra, and the thermogravimetric analysis was also studied. The drug release studies in vitro showed that the amount of 4-ASA released from the complex was about 4%, 56% and 17% after 12 h at pH 1.2, 6.8 and 7.4, respectively. The data demonstrate that the rate of the drug release of the complex can be more effectively controlled by pH value. The results showed that the novel pH-sensitive complex could be potentially useful for colon-targeting drug delivery system.

引用

页码：24 / 27

页数：4

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