Synthesis, characterization, and controllable drug release of pH-sensitive hybrid magnetic nanoparticles

被引：63

作者：

Zhou, Lilin ^{[1
]}

Yuan, Jinying ^{[1
]}

Yuan, Weizhong ^{[1
]}

Sui, Xiaofeng ^{[1
]}

Wu, Sizhu ^{[2
]}

Li, Zhaolong ^{[1
]}

Shen, Dezhong

机构：

[1] Tsinghua Univ, Dept Chem, Key Lab Organ Optoelect & Mol Engn, Minist Educ, Beijing 100084, Peoples R China

[2] Beijing Univ Chem Technol, Key Lab Sci & Technol Controlled Chem React, Beijing 100029, Peoples R China

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2009年 / 321卷 / 18期

基金：

中国国家自然科学基金;

关键词：

Targeted drug delivery; PH-responsive; Hybrid nanoparticle; Magnetite; Atom transfer radical polymerization; TRANSFER RADICAL POLYMERIZATION; RING-OPENING POLYMERIZATION; 2-(DIMETHYLAMINO)ETHYL METHACRYLATE; COMPOSITE NANOPARTICLES; BIOMEDICAL APPLICATIONS; METHYL-METHACRYLATE; BLOCK-COPOLYMER; MICROSPHERES; POLY(EPSILON-CAPROLACTONE); ATRP;

D O I：

10.1016/j.jmmm.2009.04.020

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The synthesis of magnetite nanoparticles coated with pH-sensitive poly((2-dimethylamino) ethyl methacrylate)(PDMAEMA) via atom transfer radical polymerization(ATRP) for use as novel potential carriers for targeted drug delivery and controllable release is reported. The organic/inorganic hybrid nanoparticles were obtained with an arrow molecular weight distribution. The pH-sensitivity of the nanoparticles was investigated by the measurement of the pH dependence of hydrodynamic radius and the superparamagnetism was illustrated by vibrating sample magnetometer(VSM). The behavior of model drug phenolphthalein released from the nanoparticles indicated that the rate of drug release could be effectively controlled by altering the pH values of the environment. (C) 2009 Elsevier B. V. All rights reserved.

引用

页码：2799 / 2804

页数：6

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