A simple organocatalytic enantioselective cyclopropanation of α,β-unsaturated aldehydes

被引：167
|
作者：
Rios, Ramon [1 ]
Sunden, Henrik [1 ]
Vesely, Jan [1 ]
Zhao, Gui-Ling [1 ]
Dziedzic, Pawel [1 ]
Cordova, Armando [1 ]
机构：
[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2007年 / 349卷 / 07期
关键词：
asymmetric catalysis; cyclopropanes; domino reactions; halomalonates; organocatalysis; alpha; beta-unsaturated aldehydes;
D O I：
10.1002/adsc.200700032
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A highly chemo- and enantioselective organocatalytic cyclopropanation of alpha,beta-unsaturated aldehydes with bromomalonate and 2-bromoacetoacetate esters is presented. The reaction is catalyzed by chiral amines and gives access to 2-formylcyclopropanes in high yields and up to 99% ee.
引用
收藏
页码：1028 / 1032
页数：5
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