A simple organocatalytic enantioselective cyclopropanation of α,β-unsaturated aldehydes

被引：167

作者：

Rios, Ramon ^{[1
]}

Sunden, Henrik ^{[1
]}

Vesely, Jan ^{[1
]}

Zhao, Gui-Ling ^{[1
]}

Dziedzic, Pawel ^{[1
]}

Cordova, Armando ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2007年 / 349卷 / 07期

关键词：

asymmetric catalysis; cyclopropanes; domino reactions; halomalonates; organocatalysis; alpha; beta-unsaturated aldehydes;

D O I：

10.1002/adsc.200700032

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A highly chemo- and enantioselective organocatalytic cyclopropanation of alpha,beta-unsaturated aldehydes with bromomalonate and 2-bromoacetoacetate esters is presented. The reaction is catalyzed by chiral amines and gives access to 2-formylcyclopropanes in high yields and up to 99% ee.

引用

页码：1028 / 1032

页数：5

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