Metal-Free Transamidation of Primary Amides using Trimethylsilyl Chloride

被引：19
|
作者：
Yu, Subeen [1 ]
Song, Kwang Ho [2 ]
Lee, Sunwoo [1 ]
机构：
[1] Chonnam Natl Univ, Dept Chem, Gwangju 61186, South Korea
[2] Korea Univ, Dept Chem & Biol Engn, Seoul 02841, South Korea
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 8卷 / 09期
基金：
新加坡国家研究基金会;
关键词：
transamidation; metal-free chemistry; amides; amines; trimethylsilyl chloride; CATALYZED TRANSAMIDATION; EFFICIENT CATALYST; CARBOXYLIC-ACIDS; SECONDARY AMIDES; CARBOXAMIDES; AMINES; SOLVENT; UREAS; COMPLEX;
D O I：
10.1002/ajoc.201900216
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A metal-free transamidation of primary amides was developed. Trimethylsilyl chloride (TMSCl) acted as the activator in transamidation. In the presence of TMSCl, primary amides reacted with primary amines to yield transamidated secondary amides in NMP solvent. The transamidation of benzamide with secondary amines for the formation of tertiary amides succeeds in an NMP/CHCl3 solvent mixture.
引用
收藏
页码：1613 / 1616
页数：4
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