Synthesis of 5,4"-di-O-succinoylavermectin B1

被引：12
|
作者：
Chernoburova, E. I. [1 ]
Danchenko, K. V. [1 ]
Shchetinina, M. A. [1 ]
Zharov, A. A. [1 ]
Kolobov, A. V. [2 ]
Dzhafarov, M. Kh. [3 ]
Vasilevich, F. I. [3 ]
Zavarzin, I. V. [1 ]
机构：
[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prosp, Moscow 119991, Russia
[2] Yaroslavl State Tech Univ, 88 Moskovskii Prosp, Yaroslavl 150023, Russia
[3] KI Skryabin Moscow State Acad Vet Med & Biotechno, 23 Ul Akad Skryabina, Moscow 119991, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2016年 / 65卷 / 12期
基金：
俄罗斯科学基金会;
关键词：
ultrahigh pressure; avermectin B-1; succinic anhydride; 5,4 ''-di-O-succinoylavermectin B-1; acylation reaction; antiparasitic activity; IVERMECTIN; PARASITES; TOXICITY;
D O I：
10.1007/s11172-016-1684-5
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A reaction of avermectin B-1 with succinic anhydride at ultrahigh pressure (10 kbar) gave previously unavailable 5,4"-di-O-succinoylavermectin B-1, which is of interest as potential antiparasitic agent.
引用
收藏
页码：2952 / 2955
页数：4
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