Experimental design and the optimization of a polymer supported palladium complex for use in the Heck reaction

被引：25
|
作者：
McNamara, CA
King, F
Bradley, M [1 ]
机构：
[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England
[2] Johnson Matthey Res & Technol, Billingham TS23 1LB, Cleveland, England
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 44期
基金：
英国工程与自然科学研究理事会;
关键词：
design; polymer; supported; palladium;
D O I：
10.1016/j.tetlet.2004.09.016
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Optimization of the Heck reaction of 4-bromoacetophenone with styrene by a polymer supported, sulfur-containing palladacycle, varying 6 factors at a total of 28 different levels, corresponding to 5760 different possibilities was undertaken. Conversion improved from 34%, with large observable leaching to 88% with no leaching. This was accomplished using a Design of Experiments approach facilitated by the Statistical Design Package, MODDE 7.0(TM). (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8239 / 8243
页数：5
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