Experimental design and the optimization of a polymer supported palladium complex for use in the Heck reaction

被引：25

作者：

McNamara, CA

King, F

Bradley, M ^{[1
]}

机构：

[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

[2] Johnson Matthey Res & Technol, Billingham TS23 1LB, Cleveland, England

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 44期

基金：

英国工程与自然科学研究理事会;

关键词：

design; polymer; supported; palladium;

D O I：

10.1016/j.tetlet.2004.09.016

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Optimization of the Heck reaction of 4-bromoacetophenone with styrene by a polymer supported, sulfur-containing palladacycle, varying 6 factors at a total of 28 different levels, corresponding to 5760 different possibilities was undertaken. Conversion improved from 34%, with large observable leaching to 88% with no leaching. This was accomplished using a Design of Experiments approach facilitated by the Statistical Design Package, MODDE 7.0(TM). (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：8239 / 8243

页数：5

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