Evaluation of Cytotoxic Effect of Onosma armeniacum Extract on Various Cancer Cells

被引：5
|
作者：
Demir, Selim [1 ]
Ayazoglu Demir, Elif [2 ]
Turan, Ibrahim [3 ]
Ozgen, Ufuk [4 ]
机构：
[1] Karadeniz Tech Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-61080 Trabzon, Turkey
[2] Karadeniz Tech Univ, Macka Vocat High Sch, Dept Chem & Chem Proc Technol, TR-61750 Trabzon, Turkey
[3] Gumushane Univ, Fac Engn & Nat Sci, Dept Genet & Bioengn, TR-29100 Gumushane, Turkey
[4] Karadeniz Tech Univ, Fac Pharm, Dept Pharmacognosy, TR-61080 Trabzon, Turkey
来源：
KSU TARIM VE DOGA DERGISI-KSU JOURNAL OF AGRICULTURE AND NATURE | 2021年 / 24卷 / 02期
关键词：
Antioxidant activity; Cancer; Cell culture; Cytotoxicity; Onosma armeniacum; RADICAL-SCAVENGING ACTIVITY; DORYCNIUM-PENTAPHYLLUM; PHYTOCHEMICAL ANALYSIS; ANTIOXIDANT PROPERTIES; TURKISH PROPOLIS; CYCLE ARREST; NAPHTHOQUINONES; ANTIBACTERIAL; APOPTOSIS; BREAST;
D O I：
10.18016/ksutarimdoga.vi.729814
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
The aim of this study was to investigate the antioxidant properties of the root extract of Onosma armeniacum and its cytotoxic effect against human liver (HepG2), lung (A549) and colon (WiDr) cancer cell lines compared with a normal fibroblast cell line. Antioxidant properties of the extract was determined using the colorimetric methods. The cytotoxic effect of the extract were investigated using MTT assay. The total phenolic content and reducing power values of extract were 26.1 +/- 0.4 mg gallic acid equivalent and 52.6 +/- 1.1 mg trolox equivalent per g sample, respectively. The extract exhibited selective cytotoxic effect in all studied cancer cell lines, especially HepG2 (3.6-fold). The results of this study reveal that O. armeniacum, which has been found to have acceptable antioxidant and cytotoxic effects, should be examined with more comprehensive studies.
引用
收藏
页码：252 / 259
页数：8
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