Evaluation of Cytotoxic Effect of Onosma armeniacum Extract on Various Cancer Cells

被引：5
|
作者：
Demir, Selim [1 ]
Ayazoglu Demir, Elif [2 ]
Turan, Ibrahim [3 ]
Ozgen, Ufuk [4 ]
机构：
[1] Karadeniz Tech Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-61080 Trabzon, Turkey
[2] Karadeniz Tech Univ, Macka Vocat High Sch, Dept Chem & Chem Proc Technol, TR-61750 Trabzon, Turkey
[3] Gumushane Univ, Fac Engn & Nat Sci, Dept Genet & Bioengn, TR-29100 Gumushane, Turkey
[4] Karadeniz Tech Univ, Fac Pharm, Dept Pharmacognosy, TR-61080 Trabzon, Turkey
来源：
KSU TARIM VE DOGA DERGISI-KSU JOURNAL OF AGRICULTURE AND NATURE | 2021年 / 24卷 / 02期
关键词：
Antioxidant activity; Cancer; Cell culture; Cytotoxicity; Onosma armeniacum; RADICAL-SCAVENGING ACTIVITY; DORYCNIUM-PENTAPHYLLUM; PHYTOCHEMICAL ANALYSIS; ANTIOXIDANT PROPERTIES; TURKISH PROPOLIS; CYCLE ARREST; NAPHTHOQUINONES; ANTIBACTERIAL; APOPTOSIS; BREAST;
D O I：
10.18016/ksutarimdoga.vi.729814
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
The aim of this study was to investigate the antioxidant properties of the root extract of Onosma armeniacum and its cytotoxic effect against human liver (HepG2), lung (A549) and colon (WiDr) cancer cell lines compared with a normal fibroblast cell line. Antioxidant properties of the extract was determined using the colorimetric methods. The cytotoxic effect of the extract were investigated using MTT assay. The total phenolic content and reducing power values of extract were 26.1 +/- 0.4 mg gallic acid equivalent and 52.6 +/- 1.1 mg trolox equivalent per g sample, respectively. The extract exhibited selective cytotoxic effect in all studied cancer cell lines, especially HepG2 (3.6-fold). The results of this study reveal that O. armeniacum, which has been found to have acceptable antioxidant and cytotoxic effects, should be examined with more comprehensive studies.
引用
收藏
页码：252 / 259
页数：8
相关论文
共 50 条
  • [21] Phytocompounds of Anonna muricata leaves extract and cytotoxic effects on breast cancer cells
    Husna Syakirah Ab Rahman
    Wan Suriyani Wan-Ibrahim
    Norzila Ismail
    Tuan Nadrah Naim Tuan Ismail
    Siti Farhanah Mohd-Salleh
    Michael Pak-Kai Wong
    Mohd Ridzuan Abdul Samad
    Mohd Nizam Md Hashim
    Asian Pacific Journal of Tropical Medicine, 2018, 11 (12) : 659 - 665
  • [22] Cytotoxic and Antitumor Effects of the Hydroalcoholic Extract of Tagetes erecta in Lung Cancer Cells
    Cuellar Gonzalez, Alma Sarahi
    Galvan Valencia, Marisol
    Daniel Cervantes-Villagrana, Rodolfo
    Bocanegra Zapata, Alondra
    Rafael Cervantes-Villagrana, Alberto
    MOLECULES, 2023, 28 (20):
  • [23] Assessing the cytotoxic potential of glycoalkaloidic extract in nanoparticles against bladder cancer cells
    Miranda, Mariza A.
    Marcato, Priscyla D.
    Carvalho, Ivana P. S.
    Silva, Leticia B.
    Ribeiro, Diego L.
    Amaral, Robson
    Swiech, Kamilla
    Bastos, Jairo K.
    Paschoal, Jonas A. R.
    dos Reis, Rodolfo B.
    Bentley, Maria V. L. B.
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2019, 71 (10) : 1520 - 1531
  • [24] Cytotoxic Activity of the Methanolic Extract of Turnera diffusa Willd on Breast Cancer Cells
    del Carmen Avelino-Flores, Maria
    del Carmen Cruz-Lopez, Maria
    Jimenez-Montejo, Fabiola E.
    Reyes-Leyva, Julio
    JOURNAL OF MEDICINAL FOOD, 2015, 18 (03) : 299 - 305
  • [25] Phytocompounds of Anonna muricata leaves extract and cytotoxic effects on breast cancer cells
    Ab Rahman, Husna Syakirah
    Wan-Ibrahim, Wan Suriyani
    Ismail, Norzila
    Ismail, Tuan Nadrah Naim Tuan
    Mohd-Salleh, Siti Farhanah
    Wong, Michael Pak-Kai
    Samad, Mohd Ridzuan Abdul
    Hashim, Mohd Nizam Md
    ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE, 2018, 11 (12) : 659 - 665
  • [26] Investigation of the Cytotoxic Effect of Ethyl Pyruvate on Various Cancer Cell Lines
    Ayazoglu Demir, Elif
    Demir, Selim
    Turan, Ibrahim
    KSU TARIM VE DOGA DERGISI-KSU JOURNAL OF AGRICULTURE AND NATURE, 2021, 24 (01): : 49 - 56
  • [27] Cytotoxic effect of plant extract-based nanoparticles on cancerous cells: a review
    Jyotika Grewal
    Vijay Kumar
    Hemant Rawat
    Yashika Gandhi
    Ravindra Singh
    Arjun Singh
    Gajji Babu
    Narayanam Srikanth
    Sujeet K. Mishra
    Environmental Chemistry Letters, 2022, 20 : 2487 - 2507
  • [28] Cytotoxic effect of TDZ on human cervical cancer cells
    Enkhtaivan, Gansukh
    Kim, Doo Hwan
    Pandurangan, Muthuraman
    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2017, 173 : 493 - 498
  • [29] Cytotoxic effect of urushiol on human ovarian cancer cells
    Choi, JY
    Park, CS
    Choi, J
    Rhim, H
    Chun, HJ
    JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2001, 11 (03) : 399 - 405
  • [30] Cytotoxic effect of plant extract-based nanoparticles on cancerous cells: a review
    Grewal, Jyotika
    Kumar, Vijay
    Rawat, Hemant
    Gandhi, Yashika
    Singh, Ravindra
    Singh, Arjun
    Babu, Gajji
    Srikanth, Narayanam
    Mishra, Sujeet K.
    ENVIRONMENTAL CHEMISTRY LETTERS, 2022, 20 (04) : 2487 - 2507
12345