Substituted epoxides by lithiation of terminal epoxides

被引：18
|
作者：
Hodgson, DM [1 ]
Reynolds, NJ [1 ]
Coote, SJ [1 ]
机构：
[1] Univ Oxford, Chem Res Lab, Dept Chem, Oxford OX1 3TA, England
来源：
ORGANIC LETTERS | 2004年 / 6卷 / 23期
关键词：
D O I：
10.1021/ol048544j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Diamine-ligand-assisted direct hydrogen-lithium exchange allows the generation of nonstabilized (H-substituted) oxiranyllithium species and their subsequent trapping by Bu3SnCl and carbonyl-based electrophiles. This reaction provides a new concise route to alpha,beta-epoxystannanes and substituted epoxides.
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页码：4187 / 4189
页数：3
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