FOXA1 mutations influence the therapeutic response of breast cancer by altering chromatin state

被引：0

作者：

Arruabarrena-Aristorena, Amaia ^{[1
]}

Toska, Eneda ^{[2
,3
]}

机构：

[1] CIC BioGUNE, Bizkaia Technol Pk, Derio, Spain

[2] Johns Hopkins Univ, Sch Med, Dept Oncol, Sidney Kimmel Canc Ctr, Baltimore, MD 21205 USA

[3] Johns Hopkins Sch Publ Hlth, Dept Biochem & Mol Biol, Baltimore, MD USA

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2021年 / 8卷 / 03期

基金：

欧洲研究理事会;

关键词：

Breast cancer; estrogen receptor; FOXA1; mutations; chromatin regulation; endocrine therapy; TRANSCRIPTION;

D O I：

10.1080/23723556.2021.1891831

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Forkhead box protein A1 (FOXA1) is a pioneer transcription factor that contributes to chromatin opening to allow binding of estrogen receptor (ER) in ER+ breast cancer. Mutations in FOXA1 are recurrent in breast cancer but the functional consequences of these mutations remain unknown. We identified that FOXA1 mutations are associated with worse outcomes to endocrine therapy by inducing alternative chromatin profiles and gene activity in breast cancer.

引用

页数：3

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