Practical synthesis of (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid, a key component of HIV protease inhibitors

被引：0
|
作者：
Shibata, N [1 ]
Itoh, E [1 ]
Terashima, S [1 ]
机构：
[1] Sagami Chem Res Ctr, Sagamihara, Kanagawa 229, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1998年 / 46卷 / 04期
关键词：
KNI-227; HIV protease inhibitor; 3-amino-2-hydroxy-4-phenylbutyric acid; acetone cyanohydrin; diastereoselective reaction;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Synthesis of (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid was achieved by the highly diastereoselective cyanohydrin formation of (S)-2-N,N-dibenzylamino-3-phenylpropanal with acetone cyanohydrin in the presence of trimethylaluminum as a key step.
引用
收藏
页码：733 / 735
页数：3
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