LARGE-SCALE PREPARATION OF (2S,3S)-N-BOC-3-AMINO-1,2-EPOXY-4-PHENYLBUTANE - A KEY BUILDING-BLOCK FOR HIV-PROTEASE INHIBITORS

被引：45
|
作者：
BEAULIEU, PL
WERNIC, D
DUCEPPE, JS
GUINDON, Y
机构：
[1] Bio-Méga/Boehringer Ingelheim Research Inc., Laval, Que. H7S 2G5
来源：
TETRAHEDRON LETTERS | 1995年 / 36卷 / 19期
关键词：
D O I：
10.1016/0040-4039(95)00533-I
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
(2S,3S)-N-Boc-3-amino-1,2-epoxy-4-phenylbutane is prepared in four steps from commercially available N,N-dibenzyl-L-phenylalaninol. The synthesis is amenable to the preparation of kilogram quantities of enantiomerically pure material.
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收藏
页码：3317 / 3320
页数：4
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