Practical synthesis of (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid, a key component of HIV protease inhibitors

被引：0

作者：

Shibata, N ^{[1
]}

Itoh, E ^{[1
]}

Terashima, S ^{[1
]}

机构：

[1] Sagami Chem Res Ctr, Sagamihara, Kanagawa 229, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1998年 / 46卷 / 04期

关键词：

KNI-227; HIV protease inhibitor; 3-amino-2-hydroxy-4-phenylbutyric acid; acetone cyanohydrin; diastereoselective reaction;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis of (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid was achieved by the highly diastereoselective cyanohydrin formation of (S)-2-N,N-dibenzylamino-3-phenylpropanal with acetone cyanohydrin in the presence of trimethylaluminum as a key step.

引用

页码：733 / 735

页数：3

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