Carbohydrates as a reagent in multicomponent reactions: one-pot access to a new library of hydrophilic substituted pyrimidine-fused heterocycles

被引：36

作者：

Nourisefat, Maryam ^{[1
]}

Panahi, Farhad ^{[1
]}

Khalafi-Nezhad, Ali ^{[1
]}

机构：

[1] Shiraz Univ, Coll Sci, Dept Chem, Shiraz 71454, Iran

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 46期

基金：

美国国家科学基金会;

关键词：

ALKYLATING-AGENTS; STEREOSELECTIVE-SYNTHESIS; ALPHA-GLUCOSIDASE; D-GLUCOSAMINE; DERIVATIVES; SUGARS; INHIBITORS; CHEMISTRY; BINDING; CHLORAMBUCIL;

D O I：

10.1039/c4ob01791a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study a multicomponent reaction involving carbohydrate derivatives as the main component in order to prepare a new library of polyhydroxy compounds incorporating pyrimidine-fused heterocycles (PFHs) is introduced. A set of polyhydroxy functionalized PFHs were synthesized using multicomponent reactions of sugar (glucose, galactose, arabinose and lactose), barbituric acid and amines. Also, the three-component condensation reaction between D-glucosamine, aldehyde, and barbituric acid efficiently provided polyhydroxy substituted PFH derivatives in a one-pot reaction under mild and green conditions. These new one-pot reactions gave a range of polyhydroxy substituted PFHs in good to excellent yield.

引用

页码：9419 / 9426

页数：8

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