Carbohydrates as a reagent in multicomponent reactions: one-pot access to a new library of hydrophilic substituted pyrimidine-fused heterocycles

被引：36
|
作者：
Nourisefat, Maryam [1 ]
Panahi, Farhad [1 ]
Khalafi-Nezhad, Ali [1 ]
机构：
[1] Shiraz Univ, Coll Sci, Dept Chem, Shiraz 71454, Iran
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 46期
基金：
美国国家科学基金会;
关键词：
ALKYLATING-AGENTS; STEREOSELECTIVE-SYNTHESIS; ALPHA-GLUCOSIDASE; D-GLUCOSAMINE; DERIVATIVES; SUGARS; INHIBITORS; CHEMISTRY; BINDING; CHLORAMBUCIL;
D O I：
10.1039/c4ob01791a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this study a multicomponent reaction involving carbohydrate derivatives as the main component in order to prepare a new library of polyhydroxy compounds incorporating pyrimidine-fused heterocycles (PFHs) is introduced. A set of polyhydroxy functionalized PFHs were synthesized using multicomponent reactions of sugar (glucose, galactose, arabinose and lactose), barbituric acid and amines. Also, the three-component condensation reaction between D-glucosamine, aldehyde, and barbituric acid efficiently provided polyhydroxy substituted PFH derivatives in a one-pot reaction under mild and green conditions. These new one-pot reactions gave a range of polyhydroxy substituted PFHs in good to excellent yield.
引用
收藏
页码：9419 / 9426
页数：8
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