Copper-Catalyzed Direct C-3 Benzylation of Quinoxalin-2(1H)-ones with Methylarenes under Microwave Irradiation

被引：95
|
作者：
Hu, Leqian [1 ,2 ]
Yuan, Jinwei [1 ,2 ]
Fu, Junhao [1 ,2 ]
Zhang, Taotao [1 ,2 ]
Gao, Lele [1 ,2 ]
Xiao, Yongmei [1 ,2 ]
Mao, Pu [1 ,2 ]
Qu, Lingbo [1 ,2 ,3 ]
机构：
[1] Henan Univ Technol, Sch Chem & Chem Engn, Zhengzhou 450001, Henan, Peoples R China
[2] Academician Workstn Nat Med Chem Henan Prov, Zhengzhou 450001, Henan, Peoples R China
[3] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 30期
关键词：
Nitrogen heterocycles; Arenes; Benzylation; Copper; Radical reactions; Reaction mechanisms; C-H ACTIVATION; METAL-FREE; TOLUENE DERIVATIVES; N-OXIDES; BOND; ACYLATION; ARYLATION; FUNCTIONALIZATION; ISOQUINOLINE; AMINATION;
D O I：
10.1002/ejoc.201800697
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and efficient approach to the C(sp(2))-H/C(sp(3))-H oxidative coupling of quinoxalin-2(1H)-ones with methylarenes by using Cu-I as catalyst is reported. Various substrates were well tolerated in this methodology and the desired products were given in moderate-to-good yields. This reaction features good functional group compatibility and broad substrate scope.
引用
收藏
页码：4113 / 4120
页数：8
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