Direct phosphonation of quinoxalin-2(1H)-ones under transition-metal-free conditions

被引：212
|
作者：
Gao, Ming [1 ,2 ]
Li, Yi [1 ,2 ]
Xie, Lijuan [1 ,2 ]
Chauvinabc, Remi [1 ,2 ,3 ,4 ]
Cui, Xiuling [1 ,2 ]
机构：
[1] Huaqiao Univ, Engn Res Ctr Mol Med, Key Lab Xiamen Marine & Gene Drugs, Minist Educ,Inst Mol Med, Xiamen 361021, Peoples R China
[2] Huaqiao Univ, Sch Biomed Sci, Xiamen 361021, Peoples R China
[3] CNRS, Chim Coordinat Lab, 205 Route Narbonne,BP 44099, F-31077 Toulouse 4, France
[4] Univ Toulouse, UPS, INPT, F-31077 Toulouse 4, France
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 13期
关键词：
DIALKYL H-PHOSPHONATES; CARBON-PHOSPHORUS FUNCTIONALIZATION; PALLADIUM-CATALYZED PHOSPHONATION; P BOND FORMATION; C-P; REGIOSELECTIVE PHOSPHONATION; PHOSPHINE OXIDES; ACIDS; ARYL; DIPHENYLPHOSPHINE;
D O I：
10.1039/c5cc08049e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A direct C-H bond phosphonation of quinoxalin-2(1H)-ones with H-phosphonates, H-phosphinates or H-phosphine oxides has been developed. A wide variety of heteroaryl phosphonates were obtained in up to 92% yield for 20 examples under transition-metal-free conditions. This protocol tolerates a broad scope of substrates and features practicality, high efficiency, environmental friendliness and atom economy.
引用
收藏
页码：2846 / 2849
页数：4
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