The TGFβ-Par6 polarity pathway Linking the Par complex to EMT and breast cancer progression

被引：28
|
作者：
Viloria-Petit, Alicia M. [2 ]
Wrana, Jeffrey L. [1 ,3 ]
机构：
[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Program Mol Biol & Canc, Toronto, ON M5G 1X5, Canada
[2] Univ Guelph, Ontario Vet Coll, Dept Biomed Sci, Guelph, ON N1G 2W1, Canada
[3] Univ Toronto, Dept Mol Genet & Microbiol, Toronto, ON, Canada
来源：
CELL CYCLE | 2010年 / 9卷 / 04期
关键词：
TGF beta signaling; Par6; epithelial-mesenchymal transition; cell polarity; cancer invasion; metastasis; breast cancer; MESENCHYMAL TRANSITION; CELL POLARITY; PROTEIN PAR6; PLASTICITY; MIGRATION;
D O I：
10.4161/cc.9.4.10779
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
引用
收藏
页码：623 / 624
页数：2
相关论文
共 50 条
  • [31] G-protein-activated phospholipase C-β, new partners for cell polarity proteins Par3 and Par6
    Yi Cai
    Lewis J Stafford
    Brad A Bryan
    Dianne Mitchell
    Mingyao Liu
    [J]. Oncogene, 2005, 24 : 4293 - 4300
  • [32] The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
    Joberty, G
    Petersen, C
    Gao, L
    Macara, IG
    [J]. NATURE CELL BIOLOGY, 2000, 2 (08) : 531 - 539
  • [33] Two PAR6 proteins become asymmetrically localized during establishment of polarity in mouse oocytes
    Vinot, S
    Le, T
    Maro, B
    Louvet-Vallée, S
    [J]. CURRENT BIOLOGY, 2004, 14 (06) : 520 - 525
  • [34] G-protein-activated phospholipase C-β, new partners for cell polarity proteins Par3 and Par6
    Cai, Y
    Stafford, LJ
    Bryan, BA
    Mitchell, D
    Liu, MY
    [J]. ONCOGENE, 2005, 24 (26) : 4293 - 4300
  • [35] The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
    Gérard Joberty
    Clark Petersen
    Lin Gao
    Ian G. Macara
    [J]. Nature Cell Biology, 2000, 2 : 531 - 539
  • [36] PAR3-PAR6-atypical PKC polarity complex proteins in neuronal polarization
    Hapak, Sophie M.
    Rothlin, Carla V.
    Ghosh, Sourav
    [J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2018, 75 (15) : 2735 - 2761
  • [37] Where Polarity Meets Fusion: Role of Par6 in Trophoblast Differentiation during Placental Development and Preeclampsia
    Sivasubramaniyam, Tharini
    Garcia, Julia
    Tagliaferro, Andrea
    Melland-Smith, Megan
    Chauvin, Sarah
    Post, Martin
    Todros, Tullia
    Caniggia, Isabella
    [J]. ENDOCRINOLOGY, 2013, 154 (03) : 1296 - 1309
  • [38] Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Cζ (PKCζ) and regulates PKCξ activity
    Liu, XF
    Ishida, H
    Raziuddin, R
    Miki, T
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (15) : 6665 - 6675
  • [39] Disruption of the Cdc42/Par6/aPKC or Dlg/Scrib/Lgl Polarity Complex Promotes Epithelial Proliferation via Overlapping Mechanisms
    Schimizzi, Gregory V.
    Maher, Meghan T.
    Loza, Andrew J.
    Longmore, Gregory D.
    [J]. PLOS ONE, 2016, 11 (07):
  • [40] TGFβ and BMP-2 regulate epicardial cell invasion via TGFβR3 activation of the Par6/Smurf1/RhoA pathway
    Sanchez, Nora S.
    Barnett, Joey V.
    [J]. CELLULAR SIGNALLING, 2012, 24 (02) : 539 - 548
12345