The TGFβ-Par6 polarity pathway Linking the Par complex to EMT and breast cancer progression

被引：28
|
作者：
Viloria-Petit, Alicia M. [2 ]
Wrana, Jeffrey L. [1 ,3 ]
机构：
[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Program Mol Biol & Canc, Toronto, ON M5G 1X5, Canada
[2] Univ Guelph, Ontario Vet Coll, Dept Biomed Sci, Guelph, ON N1G 2W1, Canada
[3] Univ Toronto, Dept Mol Genet & Microbiol, Toronto, ON, Canada
来源：
CELL CYCLE | 2010年 / 9卷 / 04期
关键词：
TGF beta signaling; Par6; epithelial-mesenchymal transition; cell polarity; cancer invasion; metastasis; breast cancer; MESENCHYMAL TRANSITION; CELL POLARITY; PROTEIN PAR6; PLASTICITY; MIGRATION;
D O I：
10.4161/cc.9.4.10779
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
引用
收藏
页码：623 / 624
页数：2
相关论文
共 50 条
  • [21] The polarity protein Par6 is coupled to the microtubule network during molluscan early embryogenesis
    Homma, Taihei
    Shimizu, Miho
    Kuroda, Reiko
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 404 (01) : 173 - 178
  • [22] Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6
    Garrard, SM
    Capaldo, CT
    Gao, L
    Rosen, MK
    Macara, IG
    Tomchick, DR
    [J]. EMBO JOURNAL, 2003, 22 (05): : 1125 - 1133
  • [23] Atypical PKC and TGFβ receptors co-operate to phosphorylate Par6
    Gunaratne, Adrian
    Di Guglielmo, John
    [J]. CANCER RESEARCH, 2011, 71
  • [24] Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition
    Zhang, K.
    Zhao, H.
    Ji, Z.
    Zhang, C.
    Zhou, P.
    Wang, L.
    Chen, Q.
    Wang, J.
    Zhang, P.
    Chen, Z.
    Zhu, H. H.
    Gao, W-Q
    [J]. ONCOGENE, 2016, 35 (10) : 1271 - 1282
  • [25] Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition
    K Zhang
    H Zhao
    Z Ji
    C Zhang
    P Zhou
    L Wang
    Q Chen
    J Wang
    P Zhang
    Z Chen
    H H Zhu
    W-Q Gao
    [J]. Oncogene, 2016, 35 : 1271 - 1282
  • [26] Downregulation of PKC∈/par3/par6 polarity complex is critical for hypoxia-induced epithelial-mesenchymal transition, migration, and invasion in lung cancer cells
    Zhou, Qiyuan
    Chen, Tianji
    Ibe, Joyce Christina F.
    Raj, J. Usha
    Zhou, Guofei
    [J]. CANCER RESEARCH, 2012, 72
  • [27] Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains
    Hirano, Y
    Yoshinaga, S
    Takeya, R
    Suzuki, NN
    Horiuchi, M
    Kohjima, M
    Sumimoto, H
    Inagaki, F
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (10) : 9653 - 9661
  • [28] Structural Organization of Human Full-Length PAR3 and the aPKC–PAR6 Complex
    Le T. M. Le
    Srdja Drakulic
    Jens R. Nyengaard
    Monika M. Golas
    Bjoern Sander
    [J]. Molecular Biotechnology, 2022, 64 : 1319 - 1327
  • [29] Interaction of CR1 with Par3/Par6 polarity complex mediates anti-inflammatory reprogramming of neutrophils during phagocytosis.
    Ghiran, Ionita
    Glodek, Alecsandra
    Chang, Robert
    Nicholson-Weller, Anne
    Lawler, Matthew
    [J]. JOURNAL OF IMMUNOLOGY, 2012, 188
  • [30] The Cdc42/Par6/aPKC Polarity Complex Regulates Apoptosis-Induced Compensatory Proliferation in Epithelia
    Warner, Stephen J.
    Yashiro, Hanako
    Longmore, Gregory D.
    [J]. CURRENT BIOLOGY, 2010, 20 (08) : 677 - 686
12345