Synthesis of new unexpected stable mixed alkanoic, phosphonic and sulphonic (dichloromethylene)bisphosphonic anhydride esters

被引：6
|
作者：
Ahlmark, MJ [1 ]
Vepsäläinen, JJ [1 ]
机构：
[1] Univ Kuopio, Dept Chem, Kuopio 70211, Finland
来源：
TETRAHEDRON | 2000年 / 56卷 / 29期
关键词：
bisphosphonates; synthesis; mixed anhydrides;
D O I：
10.1016/S0040-4020(00)00387-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New mixed alkanoic, phosphonic and sulphonic (dichloromethylene)bisphosphonic anhydride esters [(RO)(2)P(O)CCl2- P(O)(OX)(O(-)Z(+)), (RO)(2)P(O)CCl2P(O)(OX)(OR) and (Z(+)O(-))(RO)P(O)CCL2P(O)(OX)(O(-)Z(+)); X=C(O)R, P(O)(OR)(2), SO2Me; R=CH3, C6H5, CH(CH3)(2), (CH2)(5)CH3; Z=ammonium, Na+, K+)] were selectively synthesised, and characterised by NMR spectroscopy. These new compounds are stable and bear potential bioreversible bisphosphonate protecting groups. (C) 2000 Elsevier Science Ltd. All rights reserved.
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页码：5213 / 5219
页数：7
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