Synthesis of new unexpected stable mixed alkanoic, phosphonic and sulphonic (dichloromethylene)bisphosphonic anhydride esters

被引：6

作者：

Ahlmark, MJ ^{[1
]}

Vepsäläinen, JJ ^{[1
]}

机构：

[1] Univ Kuopio, Dept Chem, Kuopio 70211, Finland

来源：

TETRAHEDRON | 2000年 / 56卷 / 29期

关键词：

bisphosphonates; synthesis; mixed anhydrides;

D O I：

10.1016/S0040-4020(00)00387-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New mixed alkanoic, phosphonic and sulphonic (dichloromethylene)bisphosphonic anhydride esters [(RO)(2)P(O)CCl2- P(O)(OX)(O(-)Z(+)), (RO)(2)P(O)CCl2P(O)(OX)(OR) and (Z(+)O(-))(RO)P(O)CCL2P(O)(OX)(O(-)Z(+)); X=C(O)R, P(O)(OR)(2), SO2Me; R=CH3, C6H5, CH(CH3)(2), (CH2)(5)CH3; Z=ammonium, Na+, K+)] were selectively synthesised, and characterised by NMR spectroscopy. These new compounds are stable and bear potential bioreversible bisphosphonate protecting groups. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：5213 / 5219

页数：7

共 48 条

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