Expansion of CD56Bright natural killer cells in the peripheral blood of multiple sclerosis patients treated with interferon-beta

被引：106
|
作者：
Saraste, M.
Irjala, H.
Airas, L.
机构：
[1] Univ Turku, Dept Neurol, FIN-20521 Turku, Finland
[2] Univ Turku, Dept Otorhinolaryngol, Turku, Finland
[3] Univ Turku, MediCity Res Lab, Turku, Finland
来源：
NEUROLOGICAL SCIENCES | 2007年 / 28卷 / 03期
关键词：
interferon-beta; multiple sclerosis; NK cell; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; NK CELLS; T-CELLS; REGULATORY ROLE; DISEASE; BIOLOGY; GAMMA; IL-2;
D O I：
10.1007/s10072-007-0803-3
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We studied how interferon-beta (IFN-beta) treatment of relapsing-remitting multiple sclerosis (MS) affects subgroups of natural killer cells (NK cells). Following IFN-beta treatment, there was an expansion of CD56(Bright) NK-cells in the peripheral blood of MS patients, while at the same time the proportion of CD56(Dim) cells was diminished. In a control group, the proportion of CD56(Bright) NK-cells was significantly higher in secondary lymphoid tissues compared to the peripheral blood of the same individual. Our findings confirm that CD56(Bright) NK-cells preferably locate within the secondary lymphoid tismes, where they may interact with T cells and thereby contribute to the control of the disease activity in MS.
引用
收藏
页码：121 / 126
页数：6
相关论文
共 50 条
  • [31] Interferon-beta treatment in multiple sclerosis patients decreases the number of monocytes in peripheral blood
    Anlar, O
    Tombul, T
    Ozbek, H
    Dilek, L
    NEUROSCIENCE RESEARCH COMMUNICATIONS, 2003, 32 (02) : 77 - 81
  • [32] Dysregulation of regulatory CD56bright NK cells/T cells interactions in multiple sclerosis
    Laroni, Alice
    Armentani, Eric
    de Rosbo, Nicole Kerlero
    Ivaldi, Federico
    Marcenaro, Emanuela
    Sivori, Simona
    Gandhi, Roopali
    Weiner, Howard L.
    Moretta, Alessandro
    Mancardi, Giovanni L.
    Uccelli, Antonio
    JOURNAL OF AUTOIMMUNITY, 2016, 72 : 8 - 18
  • [33] Intratumoral CD56bright natural killer cells are associated with improved survival in bladder cancer
    Mukherjee, Neelam
    Ji, Niannian
    Tomasini, Maggie E.
    Hurez, Vincent
    Curiel, Tyler J.
    Montgomery, Maureen O.
    Braun, Andrew J.
    Nicolas, Marlo
    Flores, Marcela A.
    Liu, Qianqian
    Ruan, Jianhua
    Svatek, Robert S.
    CANCER RESEARCH, 2018, 78 (13)
  • [34] Human natural killer cells:: a unique innate immunoregulatory role for the CD56bright subset
    Cooper, MA
    Fehniger, TA
    Turner, SC
    Chen, KS
    Ghaheri, BA
    Ghayur, T
    Carson, WE
    Caligiuri, MA
    BLOOD, 2001, 97 (10) : 3146 - 3151
  • [35] Intratumoral CD56bright Natural Killer cells are associated with improved survival in bladder cancer
    Mukherjee, Neelam
    Ji, Niannian
    Tomasini, Maggie E.
    Hurez, Vincent
    Curiel, Tyler J.
    Montgomery, Maureen
    Braun, Andrew J.
    Nicolas, Marlo
    Aguilera, Marcela
    Liu, Qianqian
    Ruan, Jianhua
    Svatek, Robert S.
    JOURNAL OF IMMUNOLOGY, 2018, 200 (01):
  • [36] Interferon-beta neutralising antibodies in Canadian multiple sclerosis patients treated with different interferon-beta products
    Grossberg, S. E.
    Gehshan, A.
    Long, C.
    Chuppa, S. L.
    Nicholson, K.
    Grossberg, L. D.
    MULTIPLE SCLEROSIS, 2006, 12 : S207 - S208
  • [37] Changes In The Proportions Of CD56dim And CD56bright Natural Killer Cells During And After Acute Exercise
    Suzui, Masatoshi
    Takeda, Kazuyoshi
    Yagita, Hideo
    Okumura, Ko
    Shek, Pang N.
    Shephard, Roy J.
    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2006, 38 (05): : S413 - S413
  • [38] Prediction and Characterization of CD56bright NK Cell Expansion during Daclizumab Treatment for Multiple Sclerosis
    Sheridan, James
    Zhang, Ying
    Riester, Katherine
    O'Neill, Gilmore
    Tang, Meina T.
    Elkins, Jacob
    NEUROLOGY, 2010, 74 (09) : A371 - A371
  • [39] Immunophenotype and Cytokine Profiles of Rhesus Monkey CD56bright and CD56dim Decidual Natural Killer Cells
    Dambaeva, Svetlana V.
    Durning, Maureen
    Rozner, Ann E.
    Golos, Thaddeus G.
    BIOLOGY OF REPRODUCTION, 2012, 86 (01)
  • [40] Regulatory CD56bright natural killer cells mediate immunomodulatory effects of IL-2Rα-targeted therapy (daclizumab) in multiple sclerosis
    Bielekova, B
    Catalfamo, M
    Reichert-Scrivner, S
    Packer, A
    Cerna, M
    Waldmann, TA
    McFarland, H
    Henkart, PA
    Martin, R
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (15) : 5941 - 5946
12345