Expansion of CD56Bright natural killer cells in the peripheral blood of multiple sclerosis patients treated with interferon-beta

被引：106

作者：

Saraste, M.

Irjala, H.

Airas, L.

机构：

[1] Univ Turku, Dept Neurol, FIN-20521 Turku, Finland

[2] Univ Turku, Dept Otorhinolaryngol, Turku, Finland

[3] Univ Turku, MediCity Res Lab, Turku, Finland

来源：

NEUROLOGICAL SCIENCES | 2007年 / 28卷 / 03期

关键词：

interferon-beta; multiple sclerosis; NK cell; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; NK CELLS; T-CELLS; REGULATORY ROLE; DISEASE; BIOLOGY; GAMMA; IL-2;

D O I：

10.1007/s10072-007-0803-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied how interferon-beta (IFN-beta) treatment of relapsing-remitting multiple sclerosis (MS) affects subgroups of natural killer cells (NK cells). Following IFN-beta treatment, there was an expansion of CD56(Bright) NK-cells in the peripheral blood of MS patients, while at the same time the proportion of CD56(Dim) cells was diminished. In a control group, the proportion of CD56(Bright) NK-cells was significantly higher in secondary lymphoid tissues compared to the peripheral blood of the same individual. Our findings confirm that CD56(Bright) NK-cells preferably locate within the secondary lymphoid tismes, where they may interact with T cells and thereby contribute to the control of the disease activity in MS.

引用

页码：121 / 126

页数：6

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