Development and Validation of a UV-Spectrophotometric Method for Quantitative Determination of Benzene Fragments in Benzyl Esters of Heparin

被引：2
|
作者：
Matveev, A. V. [1 ]
Zhavoronok, E. S. [1 ,2 ]
Frumin, L. E. [1 ]
Yur'eva, K. P. [1 ]
Grebenkina, L. E. [1 ]
Prokorov, D. I. [1 ]
Panov, A. V. [1 ,2 ]
Kedik, S. A. [1 ,2 ]
机构：
[1] MIREA Russian Technol Univ, MV Lomonosov Inst Fine Chem Technol, 86 Vernadskogo Prosp, Moscow 119571, Russia
[2] LLC Inst Pharmaceut Technol, 21-32 Skolkovskoe Sh, Moscow 121353, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2021年 / 55卷 / 02期
关键词：
low-molecular-weight heparin; content of benzyl fragments; UV spectrophotometry; heparin benzyl ester; unfractionated heparin;
D O I：
10.1007/s11094-021-02382-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new UV-spectrophotometric method for determining the concentration of benzyl fragments in heparin benzyl esters is proposed. The method was validated for linearity, accuracy, and precision in terms of repeatability and intralaboratory reproducibility. The method is intended to characterize heparin benzyl esters, which are intermediates in the synthesis of low-molecular-weight heparin via hydrolytic depolymerization of high-molecular-weight heparin.
引用
收藏
页码：197 / 201
页数：5
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