Development and Validation of Uv-Spectrophotometric Method for Simultaneous Estimation of Naproxen and Paracetamol By Q-Absorbance Ratio Method

被引：0
|
作者：
Patel, Asha [1 ]
Firke, Sandip D. [1 ]
Bari, Sanjaykumar B. [1 ]
Ranoliya, Jatin R. [2 ]
机构：
[1] HR Patel Inst Pharmaceut Educ & Res, Shirpur, Maharashtra, India
[2] Parul Inst Pharm, Vadodara 391760, Gujarat, India
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND ALLIED SCIENCES | 2014年 / 3卷 / 01期
关键词：
Naproxen; Paracetamol; Q-absorbance ratio method; isoabsorptive point;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A simple Q-absorbance ratio UV-spectrophotometric method was developed for the simultaneous estimation of Naproxen and Paracetamol in pharmaceutical dosage form. The solvent used was 0.1N NaOH. Two wavelengths 257.00 nm (lambda(max) of Paracetamol) and 234.00 nm (Isoabsorptive point) were selected for estimation of paracetamol and naproxen for Q-Absorbance ratio method. The overlay spectrum of both drugs was used to decide the isoabsorptive point for analysis. The linearity ranges for Paracetamol (PCM) and Naproxen (NPX) were 2.5 - 5.0 mu g/ml and 1.5 - 3.0 mu g/ml respectively. The % recovery was found to be 97.91% and 98.64% for paracetamol and naproxen respectively indicating that the proposed method was accurate and precise for simultaneous estimation of naproxen and paracetamol in bulk formulations.
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页码：57 / 63
页数：7
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