Potent and selective ligands for adenosine binding sites

被引：8
|
作者：
Cristalli, G
Camaioni, E
DiFrancesco, E
Eleuteri, A
Vittori, S
Volpini, R
机构：
来源：
NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 7-9期
关键词：
D O I：
10.1080/07328319708006189
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A number of selective ligands for the different binding sites of adenosine have been synthesized and tested in several pharmacological models. The aim of these synthetic efforts is both to improve the knowledge of structure-activity relationships in the adenosine-related biological systems and to develop drugs from some of these molecules.
引用
收藏
页码：1379 / 1388
页数：10
相关论文
共 50 条
  • [31] Potent, Selective Adenosine A1 Agonists as Potential Analgesics
    P.J. Beswick
    C. Bountra
    N.M. Clayton
    S.D. Collins
    R.P.C. Cousins
    C.D. Eldred
    A. Naylor
    M.J. Sheehan
    D.J. Spalding
    Medicinal Chemistry Research, 2004, 13 : 88 - 98
  • [32] Molecular modelling of the human A2b adenosine receptor and an analysis of the binding modes of its selective ligands
    Ivanov, AA
    Baskin, II
    Palyulin, VA
    Baraldi, PG
    Zefirov, NS
    MENDELEEV COMMUNICATIONS, 2002, (06) : 211 - 212
  • [33] New potent and selective A1 adenosine receptor agonists
    Hutchinson, SA
    Baker, SP
    Linden, J
    Scammells, PJ
    BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (18) : 4877 - 4884
  • [34] N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor
    Volpini, Rosaria
    Dal Ben, Diego
    Lambertucci, Catia
    Taffi, Sara
    Vittori, Sauro
    Klotz, Karl-Norbert
    Cristalli, Gloria
    JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (06) : 1222 - 1230
  • [35] 2 POPULATIONS OF MUSCARINIC BINDING-SITES IN THE CHICK HEART DISTINGUISHED BY AFFINITIES FOR LIGANDS AND SELECTIVE INACTIVATION
    JAKUBIK, J
    TUCEK, S
    BRITISH JOURNAL OF PHARMACOLOGY, 1994, 113 (04) : 1529 - 1537
  • [36] Potent and selective, orally active adenosine A2A antagonists
    Flohr, A.
    Alanine, A.
    Moreau, J-L
    Poli, S.
    Riemer, C.
    PURINERGIC SIGNALLING, 2012, 8 (01) : 124 - 125
  • [37] CHARACTERIZATION OF NEUROKININ BINDING-SITES IN RAT-BRAIN MEMBRANES USING HIGHLY SELECTIVE LIGANDS
    HUMPEL, C
    SARIA, A
    NEUROPEPTIDES, 1993, 25 (01) : 65 - 71
  • [38] Designing Selective Protein Binding Sites
    Nerattini, Francesca
    Tubiana, Luca
    Cardelli, Chiara
    Bianco, Valentino
    Dellago, Christoph
    Coluzza, Ivan
    BIOPHYSICAL JOURNAL, 2018, 114 (03) : 409A - 409A
  • [39] Synthesis and Binding Affinity of Homologated Adenosine Analogues as A3 Adenosine Receptor Ligands
    Lee, Hyuk Woo
    Choi, Won Jun
    Jacobson, Kenneth A.
    Jeong, Lak Shin
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2011, 32 (05) : 1620 - 1624
  • [40] BIMODALITY IN THE COOPERATIVE BINDING OF LIGANDS TO MOLECULES WITH MULTIPLE BINDING-SITES
    REITER, J
    EPSTEIN, IR
    JOURNAL OF PHYSICAL CHEMISTRY, 1987, 91 (18): : 4813 - 4820
12345