Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

被引：23
|
作者：
Toscani, Anita [1 ]
Risi, Caterina [1 ]
Black, Gary W. [2 ]
Brown, Nicola L. [2 ]
Shaaban, Ali [1 ]
Turner, Nicholas J. [3 ]
Castagnolo, Daniele [1 ]
机构：
[1] Kings Coll London, Sch Canc & Pharmaceut Sci, 150 Stamford St, London SE1 9NH, England
[2] Northumbria Univ, Dept Appl Sci, Ellison Pl, Newcastle Upon Tyne NE1 8ST, Tyne & Wear, England
[3] Univ Manchester, Manchester Inst Biotechnol, Sch Chem, 131 Princess St, Manchester M1 7DN, Lancs, England
来源：
ACS CATALYSIS | 2018年 / 8卷 / 09期
基金：
英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;
关键词：
biocatalysis; MAO-N; pyridine; aromatization; tetrahydropyridine; in situ NMR; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP; SUBSTITUTED PYRIDINES; NMR; DIHYDROPYRIDINES; BIOACTIVATION; DERIVATIVES; METATHESIS; CATALYSIS; ALKYNES;
D O I：
10.1021/acscatal.8b02386
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A sustainable MAO-N biocatalyzed process for the synthesis of pyridines from aliphatic tetrahydropyridines (THP) has been developed. Pyridine compounds were synthesized under mild reaction conditions and with high conversion, exploiting MAO-N whole cells as aromatizing biocatalysts. The kinetic profile of the whole cell biocatalytic transformation was finally investigated via in situ F-19 NMR.
引用
收藏
页码：8781 / 8787
页数：13
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