Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

被引：23

作者：

Toscani, Anita ^{[1
]}

Risi, Caterina ^{[1
]}

Black, Gary W. ^{[2
]}

Brown, Nicola L. ^{[2
]}

Shaaban, Ali ^{[1
]}

Turner, Nicholas J. ^{[3
]}

Castagnolo, Daniele ^{[1
]}

机构：

[1] Kings Coll London, Sch Canc & Pharmaceut Sci, 150 Stamford St, London SE1 9NH, England

[2] Northumbria Univ, Dept Appl Sci, Ellison Pl, Newcastle Upon Tyne NE1 8ST, Tyne & Wear, England

[3] Univ Manchester, Manchester Inst Biotechnol, Sch Chem, 131 Princess St, Manchester M1 7DN, Lancs, England

来源：

ACS CATALYSIS | 2018年 / 8卷 / 09期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

biocatalysis; MAO-N; pyridine; aromatization; tetrahydropyridine; in situ NMR; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP; SUBSTITUTED PYRIDINES; NMR; DIHYDROPYRIDINES; BIOACTIVATION; DERIVATIVES; METATHESIS; CATALYSIS; ALKYNES;

D O I：

10.1021/acscatal.8b02386

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A sustainable MAO-N biocatalyzed process for the synthesis of pyridines from aliphatic tetrahydropyridines (THP) has been developed. Pyridine compounds were synthesized under mild reaction conditions and with high conversion, exploiting MAO-N whole cells as aromatizing biocatalysts. The kinetic profile of the whole cell biocatalytic transformation was finally investigated via in situ F-19 NMR.

引用

页码：8781 / 8787

页数：13

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