Two Transition Metal Coordination Polymers: Application Values in Treatment and Clinical Nursing Against Glioma

被引：0

作者：

Du, Yan ^{[1
]}

Li, Li ^{[2
]}

Zhao, Teng ^{[3
]}

Gao, Fengquan ^{[1
]}

机构：

[1] Qiqihar Med Coll, Dept Neurosurg 2, Affiliated Hosp 3, Qiqihar 161000, Peoples R China

[2] Qiqihar Med Coll, Dept Nursing, Affiliated Hosp 3, Qiqihar 161000, Peoples R China

[3] Qiqihar Med Coll, Dept Crit Care Med, Affiliated Hosp 3, Qiqihar 161000, Peoples R China

来源：

SCIENCE OF ADVANCED MATERIALS | 2022年 / 14卷 / 01期

关键词：

Coordination Polymers; Glioma; RT-PCR Assay; ORGANIC FRAMEWORKS; COMPLEXES;

D O I：

10.1166/sam.2022.4182

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In this paper, by employing the 4-(1H-2-methylimidazol-1-yl)benzoic acid (HMIBA) ligand featuring both imidazole and carboxylic acid groups, two novel coordination polymers (CPs) based on Cu(II) and Co(II), namely, [Cu(MIBA)(2)](n), (2) and [Co-2(MIBA)(4)(H2O)(6)](n) (1), were synthesized by a reaction between HMIBA and corresponding metal salts in distinct solvent systems. Their application value on the treatment and clinical nursing against gliomas was discussed, and the associated mechanism was investigated. First, the suppression activity on the proliferation of cancer cells was examined. Second, RT-PCR was accomplished for testing the activation levels of signaling pathways of p53 and Rb in cancer cells.

引用

页码：208 / 213

页数：6

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