Efficient Pd-Catalyzed Coupling of Tautomerizable Heterocycles with Terminal Alkynes via C-OH Bond Activation Using PyBrOP

被引：46

作者：

Shi, Ce ^{[1
]}

Aldrich, Courtney C. ^{[1
]}

机构：

[1] Univ Minnesota, Ctr Drug Design, Acad Hlth Ctr, Minneapolis, MN 55455 USA

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 10期

关键词：

COPPER-FREE; SIDEROPHORE BIOSYNTHESIS; SONOGASHIRA REACTIONS; DIRECT ARYLATION; ARYL CHLORIDES; BORONIC ACIDS; BROMIDES; FUNCTIONALIZATION; NUCLEOSIDES; INHIBITION;

D O I：

10.1021/ol100657n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct alkynylation of tautomerizable heterocycles is described via a two-step process involving in situ C OH activation with bromotripyrrolidinophosphonium hexafluorophosphate (PyBrOP) followed by Sonogashira coupling with a wide range of alkyl or aryl terminal alkynes using a copper-free system employing PdCl2(CH3CN)(2) and 2-(dicyclohexylphosphino)biphenyl.

引用

页码：2286 / 2289

页数：4

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