The construction of DNAzyme-based logic gates for amplified microRNA detection and cancer recognition

被引：10
|
作者：
Wu, Lingyu [1 ]
Pan, Min [1 ]
Chen, Yuqi [1 ]
Huang, Haiyan [1 ]
Zhang, Xiaoe [1 ]
Wang, Fuan [1 ]
Zhou, Xiang [1 ]
机构：
[1] Wuhan Univ, Coll Chem & Mol Sci, Key Lab Biomed Polymers, Minist Educ, Wuhan 430072, Hubei, Peoples R China
来源：
ANALYST | 2019年 / 144卷 / 24期
基金：
美国国家科学基金会;
关键词：
DNA; EXPRESSION; AMPLIFICATION; CIRCUITS;
D O I：
10.1039/c9an01977d
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Benefiting from the simple DNAzyme and a duplex-specific nuclease, a series of microRNA-stimulated DNAzyme logic gates were rationally assembled for the highly accurate detection of multiple low-abundant microRNA biomarkers that correspond to the specific aberrant microRNA expression patterns of cancer tissues, thus showing a great potential in early diagnosis.
引用
收藏
页码：7278 / 7282
页数：5
相关论文
共 50 条
  • [1] Logic reversibility and thermodynamic irreversibility demonstrated by DNAzyme-based Toffoli and Fredkin logic gates
    Orbach, Ron
    Remacle, Franoise
    Levine, R. D.
    Willner, Itamar
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (52) : 21228 - 21233
  • [2] DNAzyme-Based Dissipative DNA Strand Displacement for Constructing Temporal Logic Gates
    Hu, Minghao
    Li, Xiaolong
    Wu, Jia-ni
    Yang, Mengyao
    Wu, Tongbo
    [J]. ACS NANO, 2024, 18 (03) : 2184 - 2194
  • [3] DNAzyme-based probe for circulating microRNA detection in peripheral blood
    Shao, Guoli
    Ji, Shufeng
    Wu, Aiguo
    Liu, Cuiping
    Wang, Mengchuan
    Zhang, Pusheng
    Jiao, Qingli
    Kang, Yuzhan
    [J]. DRUG DESIGN DEVELOPMENT AND THERAPY, 2015, 9 : 6109 - 6117
  • [4] Construction and Application of DNAzyme-based Nanodevices
    Wang, Bo
    Wang, Menghui
    Peng, Fangqi
    Fu, Xiaoyi
    Wen, Mei
    Shi, Yuyan
    Chen, Mei
    Ke, Guoliang
    Zhang, Xiao-Bing
    [J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2023, 39 (01) : 42 - 60
  • [5] Construction and Application of DNAzyme-based Nanodevices
    Bo Wang
    Menghui Wang
    Fangqi Peng
    Xiaoyi Fu
    Mei Wen
    Yuyan Shi
    Mei Chen
    Guoliang Ke
    Xiao-Bing Zhang
    [J]. Chemical Research in Chinese Universities, 2023, 39 : 42 - 60
  • [6] DNAzyme-based therapeutics for cancer treatment
    Fu, Shujun
    Sun, Lun-Quan
    [J]. FUTURE MEDICINAL CHEMISTRY, 2015, 7 (13) : 1701 - 1707
  • [7] DNAzyme-based biosensors for mercury (II) detection: Rational construction, advances and perspectives
    Cheng, Zehua
    Wei, Jinchao
    Gu, Liqiang
    Zou, Liang
    Wang, Ting
    Chen, Ling
    Li, Yuqing
    Yang, Yu
    Li, Peng
    [J]. JOURNAL OF HAZARDOUS MATERIALS, 2022, 431
  • [8] Accelerated DNAzyme-based fluorescent nanoprobe for highly sensitive microRNA detection in live cells
    Wu, Yanan
    Meng, Hong-Min
    Chen, Juan
    Jiang, Kemei
    Yang, Ran
    Li, Yingying
    Zhang, Ke
    Qu, Lingbo
    Zhang, Xiao-Bing
    Li, Zhaohui
    [J]. CHEMICAL COMMUNICATIONS, 2020, 56 (03) : 470 - 473
  • [9] The Amplified DNA Logic Gates Based on Aptamer-Receptor Recognition for Cell Detection and Bioimaging
    Wang, Yajing
    Wu, Di
    Cao, Xiuping
    Guo, Yingshu
    [J]. BIOSENSORS-BASEL, 2023, 13 (11):
  • [10] Versatile DNAzyme-Based Amplified Biosensing Platforms for Nucleic Acid, Protein, and Enzyme Activity Detection
    Zhao, Xu-Hua
    Gong, Liang
    Zhang, Xiao-Bing
    Yang, Bin
    Fu, Ting
    Hu, Rong
    Tan, Weihong
    Yu, Ruqin
    [J]. ANALYTICAL CHEMISTRY, 2013, 85 (07) : 3614 - 3620
12345