Construction and Application of DNAzyme-based Nanodevices

被引：6

作者：

Wang, Bo ^{[1
]}

Wang, Menghui ^{[1
]}

Peng, Fangqi ^{[1
]}

Fu, Xiaoyi ^{[3
]}

Wen, Mei ^{[1
]}

Shi, Yuyan ^{[1
]}

Chen, Mei ^{[2
]}

Ke, Guoliang ^{[1
]}

Zhang, Xiao-Bing ^{[1
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China

[2] Hunan Univ, Coll Mat Sci & Engn, Changsha 410082, Peoples R China

[3] Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou 310022, Peoples R China

来源：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2023年 / 39卷 / 01期

基金：

中国国家自然科学基金;

关键词：

DNAzyme; Nanodevice; Biosensor; Therapy; CONSTITUTIONAL DYNAMIC NETWORKS; ROLLING CIRCLE AMPLIFICATION; G-QUADRUPLEX/HEMIN DNAZYME; IN-VITRO SELECTION; STRAND DISPLACEMENT; AMPLIFIED DETECTION; NUCLEIC-ACIDS; LOGIC GATES; METAL-IONS; DNA;

D O I：

10.1007/s40242-023-2334-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The development of stimuli-responsive nanodevices with high efficiency and specificity is very important in biosensing, drug delivery, and so on. DNAzymes are a class of DNA molecules with the specific catalytic activity. Owing to their unique catalytic activity and easy design and synthesis, the construction and application of DNAzymes-based nanodevices have attracted much attention in recent years. In this review, the classification and properties of DNAzyme are first introduced. The construction of several common kinds of DNAzyme-based nanodevices, such as DNA motors, signal amplifiers, and logic gates, is then systematically summarized. We also introduce the application of DNAzyme-based nanodevices in sensing and therapeutic fields. In addition, current limitations and future directions are discussed.

引用

页码：42 / 60

页数：19

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