Synthesis and Biological Evaluation of Hippolachnin A Analogues

被引：12
|
作者：
Timmerman, Jacob C. [1 ]
Wood, John L. [1 ]
机构：
[1] Baylor Univ, Dept Chem & Biochem, One Bear Pl 97348, Waco, TX 76798 USA
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 13期
基金：
英国惠康基金;
关键词：
CRYPTOCOCCUS-NEOFORMANS; ANTIFUNGAL AGENTS; (+/-)-HIPPOLACHNIN; CANDIDA; IDENTIFICATION; RESISTANCE; DILUTION;
D O I：
10.1021/acs.orglett.8b01381
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The marine polyketide hippolachnin A (1) has attracted considerable attention from synthetic chemists due to both its intricate core structure and attractive biological activity against virulent fungi. Described herein are recent efforts to employ our recently developed synthesis in structure activity relationship studies of 1. These studies have revealed that, in contrast to initial reports, 1 and several structural analogues lack activity against pathogenic fungi.
引用
收藏
页码：3788 / 3792
页数：5
相关论文
共 50 条
  • [1] Synthesis and Biological Evaluation of Hippolachnin A Analogues (vol 20, pg 3788, 2018)
    Timmerman, Jacob C.
    McCallum, Monica E.
    Wood, John L.
    [J]. ORGANIC LETTERS, 2019, 21 (04) : 1242 - 1242
  • [2] Synthesis and biological evaluation of (±)-hippolachnin and analogs
    Nils Winter
    Zeljka Rupcic
    Marc Stadler
    Dirk Trauner
    [J]. The Journal of Antibiotics, 2019, 72 : 375 - 383
  • [3] Synthesis and biological evaluation of (±)-hippolachnin and analogs
    Winter, Nils
    Rupcic, Zeljka
    Stadler, Marc
    Trauner, Dirk
    [J]. JOURNAL OF ANTIBIOTICS, 2019, 72 (06): : 375 - 383
  • [4] Synthesis and biological evaluation of (-)-laulimalide analogues
    Gallagher, BM
    Fang, FG
    Johannes, CW
    Pesant, M
    Tremblay, MR
    Zhao, HJ
    Akasaka, K
    Li, XY
    Liu, JK
    Littlefield, BA
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (03) : 575 - 579
  • [5] Synthesis and biological evaluation of manzamine analogues
    Winkler, Jeffrey D.
    Londregan, Allyn T.
    Ragains, Justin R.
    Hamann, Mark T.
    [J]. ORGANIC LETTERS, 2006, 8 (15) : 3407 - 3409
  • [6] Synthesis and biological evaluation of helioxanthin analogues
    Janmanchi, Damodar
    Lin, Chih Hsiu
    Hsieh, Jui-yu
    Tseng, Ya-ping
    Chen, Tai-an
    Jhuang, Hong-jhih
    Yeh, Sheau Farn
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (07) : 2163 - 2176
  • [7] Synthesis and Biological Evaluation of Febrifugine Analogues
    Huong Doan Thi Mai
    Giang Vo Thanh
    Van Hieu Tran
    Van Nam Vu
    Van Loi Vu
    Cong Vinh Le
    Thuy Linh Nguyen
    Thi Dao Phi
    Bich Ngan Truong
    Van Minh Chau
    Van Cuong Pham
    [J]. NATURAL PRODUCT COMMUNICATIONS, 2014, 9 (12) : 1717 - 1720
  • [8] Synthesis and biological evaluation of (-)-laulimalide analogues
    Wender, PA
    Hegde, SG
    Hubbard, RD
    Zhang, L
    Mooberry, SL
    [J]. ORGANIC LETTERS, 2003, 5 (19) : 3507 - 3509
  • [9] Synthesis and biological evaluation of hydrazidomycin analogues
    Meyer, Florian
    Ueberschaar, Nico
    Dahse, Hans-Martin
    Hertweck, Christian
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (22) : 6043 - 6045
  • [10] Synthesis and Biological Evaluation of (-) and (+)-Spiroleucettadine and Analogues
    Badart, Michael P.
    Barnes, Emma M.
    Cording, Andrew P.
    Gilmer, Selena C. L.
    Billinghurst, Ian D.
    Edupuganti, Veera V. Shivaji R.
    Lessene, Guillaume
    Bland, Abigail R.
    Bower, Rebekah L.
    Rana, Zohaib
    Ferguson, Scott A.
    Opel Reading, Helen K.
    Cook, Gregory M.
    Rosengren, Rhonda J.
    Krause, Kurt L.
    Gamble, Allan B.
    Ashton, John C.
    Hawkins, Bill C.
    [J]. CHEMMEDCHEM, 2021, 16 (08) : 1308 - 1315
12345