Synthesis and Biological Evaluation of Hippolachnin A Analogues

被引：12

作者：

Timmerman, Jacob C. ^{[1
]}

Wood, John L. ^{[1
]}

机构：

[1] Baylor Univ, Dept Chem & Biochem, One Bear Pl 97348, Waco, TX 76798 USA

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 13期

基金：

英国惠康基金;

关键词：

CRYPTOCOCCUS-NEOFORMANS; ANTIFUNGAL AGENTS; (+/-)-HIPPOLACHNIN; CANDIDA; IDENTIFICATION; RESISTANCE; DILUTION;

D O I：

10.1021/acs.orglett.8b01381

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The marine polyketide hippolachnin A (1) has attracted considerable attention from synthetic chemists due to both its intricate core structure and attractive biological activity against virulent fungi. Described herein are recent efforts to employ our recently developed synthesis in structure activity relationship studies of 1. These studies have revealed that, in contrast to initial reports, 1 and several structural analogues lack activity against pathogenic fungi.

引用

页码：3788 / 3792

页数：5

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