Synthesis and biological evaluation of (±)-hippolachnin and analogs

被引：14

作者：

Winter, Nils ^{[1
]}

Rupcic, Zeljka ^{[2
]}

Stadler, Marc ^{[2
]}

Trauner, Dirk ^{[1
,3
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Dept Chem, Butenandtstr 5-13, D-81377 Munich, Germany

[2] Helmholtz Ctr InfectionRes, Inhoffenstr 7, D-38124 Braunschweig, Germany

[3] NYU, Dept Chem, Silver Ctr, 100 Washington Sq East,Room 712, New York, NY 10003 USA

来源：

JOURNAL OF ANTIBIOTICS | 2019年 / 72卷 / 06期

关键词：

11-STEP TOTAL-SYNTHESIS; THIOCARBONYL YLIDES; ENAMINE REACTIONS; NEW-GENERATION; MECHANISM; CARBONYL; CYCLOADDITIONS; METABOLITES; HYDROLYSIS; REAGENTS;

D O I：

10.1038/s41429-019-0176-x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Due its unique structure and its reported potent antifungal activity, the marine polyketide hippolachnin A (1) has attracted much attention in the synthetic community. Herein, we describe the development of a concise, diversifiable and scalable synthesis of the racemic natural product, which serves as a platform for the generation of bioactive analogues. Biological testing of our synthetic material did not confirm the reported antifungal activity of hippolachnin A but unraveled moderate activity against nematodes and microbes.

引用

页码：375 / 383

页数：9

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