Synthesis, crystal structure and biological activity of 2-[2-(quinolin-2-yl)vinyl]-8-hydroxyquinoline and 2-[2-(quinolin-4-yl)vinyl]-8-hydroxyquinoline

被引：6

作者：

Zeng, He-Ping ^{[1
]}

Wang, Ting-Ting

Xu, Dan-Feng

Cai, Yue-Peng

Chen, Dong-Feng

机构：

[1] S China Univ Technol, Sch Chem, Inst Funct Mol, Guangzhou 510641, Peoples R China

[2] S China Normal Univ, Sch Chem & Environm, Guangzhou 510631, Peoples R China

[3] Guangzhou Univ Tradit Chinese Med, Guangzhou 510405, Peoples R China

来源：

JOURNAL OF APPLIED CRYSTALLOGRAPHY | 2007年 / 40卷

关键词：

D O I：

10.1107/S0021889807007704

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two new isomeric 8-hydroxyquinoline derivatives with quinoline groups have been synthesized by Perkin condensation. Their structures were characterized by EI-MS, H-1 NMR spectroscopy, elemental analysis and FT-IR spectroscopy; crystal structures were determined by X-ray crystallography. 2-[2-(Quinolin-2-yl) vinyl]-8-hydroxyquinoline crystallizes in the tetragonal space group I4(1)/a and 2-[2-(quinolin-4-yl)vinyl]-8-hydroxyquinoline crystallizes in the monoclinic space group P2(1)/n. Hydrogen bonds and intermolecular interactions are observed in the compounds and stabilize their structures. The biological activities were investigated by MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay and flow cytometry analysis, and the results revealed that the two compounds had effects on the proliferation of rat mesenchymal stem cells.

引用

页码：471 / 475

页数：5

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