Photodynamic efficiency of protoporphyrin IX: Comparison of endogenous protoporphyrin IX induced by 5-aminolevulinic acid and exogenous porphyrin IX

被引：46
|
作者：
Tabata, K [1 ]
Ogura, S [1 ]
Okura, I [1 ]
机构：
[1] Tokyo Inst Technol, Dept Bioengn, Yokohama, Kanagawa 226, Japan
来源：
PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1997年 / 66卷 / 06期
关键词：
D O I：
10.1111/j.1751-1097.1997.tb03235.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Photodynamic efficiency of protoporphyrin IX (PP) accumulated in HeLa cells by the incubation of PP with HeLa cells was compared with that of accumulated PP formed from 5-aminolevulinic acid (ALA) as a precursor. The ALA-induced PP was photodynamically more efficient than exogenous PP. The difference is caused by monomeric PP concentration and PP localization site in HeLa cells. Exogenous PP was accumulated mainly in plasma membrane, and the membrane was strongly damaged by irradiation. The ALA-induced PP was selectively accumulated in mitochondria and inactivated the mitochondrial function by irradiation.
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页码：842 / 846
页数：5
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