Photodynamic efficiency of protoporphyrin IX: Comparison of endogenous protoporphyrin IX induced by 5-aminolevulinic acid and exogenous porphyrin IX

被引：46

作者：

Tabata, K ^{[1
]}

Ogura, S ^{[1
]}

Okura, I ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Bioengn, Yokohama, Kanagawa 226, Japan

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1997年 / 66卷 / 06期

关键词：

D O I：

10.1111/j.1751-1097.1997.tb03235.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Photodynamic efficiency of protoporphyrin IX (PP) accumulated in HeLa cells by the incubation of PP with HeLa cells was compared with that of accumulated PP formed from 5-aminolevulinic acid (ALA) as a precursor. The ALA-induced PP was photodynamically more efficient than exogenous PP. The difference is caused by monomeric PP concentration and PP localization site in HeLa cells. Exogenous PP was accumulated mainly in plasma membrane, and the membrane was strongly damaged by irradiation. The ALA-induced PP was selectively accumulated in mitochondria and inactivated the mitochondrial function by irradiation.

引用

下载

页码：842 / 846

页数：5

共 50 条

[21] Wavelength-dependent in vitro and in vivo photodynamic effects after sensitization with 5-aminolevulinic acid induced protoporphyrin IX
Szeimies, RM
Abels, C
Fritsch, C
Steinbach, P
Baumler, W
Karrer, S
Messmann, H
Goetz, AE
Goerz, G
Landthaler, M
PHOTOCHEMOTHERAPY: PHOTODYNAMIC THERAPY AND OTHER MODALITIES, PROCEEDINGS OF, 1996, 2625 : 44 - 47
[22] Formation of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PPIX) and photodynamic effectiveness in human urothelial cell lines
Seidl, J
Krieg, RC
Rauch, J
Waidelich, R
Stepp, H
Knüchel, R
CLINICAL LASERS AND DIAGNOSTICS, 2000, 4156 : 46 - 53
[23] Plasma levels of protoporphyrin IX in humans after oral administration of 5-aminolevulinic acid
Webber, J
Kessel, D
Fromm, D
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1997, 37 (1-2) : 151 - 153
[24] Synthesis and evaluation of unsaturated alkyl esters of 5-aminolevulinic acid as precursors to protoporphyrin IX
Jo, Choonsil
Jo, Yun Ju
Park, Hyoung-Ryun
Lee, Jee-Bum
Kwon, Yong-Hyun
Lee, Sunwoo
Chun, Keun Ho
Oh, Jonghoon
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2007, 28 (01): : 129 - 132
[25] Plasma protoporphyrin IX following administration of 5-aminolevulinic acid as a potential tumor marker
Ota, Urara
Fukuhara, Hideo
Ishizuka, Masahiro
Abe, Fuminori
Kawada, Chiaki
Tamura, Kenji
Tanaka, Tohru
Inoue, Keiji
Ogura, Shun-Ichiro
Shuin, Taro
MOLECULAR AND CLINICAL ONCOLOGY, 2015, 3 (04) : 797 - 801
[26] Photobleaching behavior of protoporphyrin IX during 5-aminolevulinic acid marked glioblastoma detection
Haj-Hosseini, Neda
Richter, Johan
Andersson-Engels, Stefan
Wardell, Karin
PHOTONIC THERAPEUTICS AND DIAGNOSTICS V, 2009, 7161
[27] In vivo pharmacokinetics of protoporphyrin IX accumulation following intracutaneous injection of 5-aminolevulinic acid
de Blois, AW
Thissen, MRTM
de Bruijn, HS
Grouls, RJE
Dutrieux, RP
Robinson, DJ
Neumann, HAM
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2001, 61 (1-2) : 21 - 29
[28] Effect of 5-Aminolevulinic Acid Dose and Estrogen on Protoporphyrin IX Concentrations in the Rat Uterus
Brenda N. Roy
Dean A. Van Vugt
Glenn E. Weagle
Roy H. Pottier
Robert L. Reid
The Journal of the Society for Gynecologic Investigation: JSGI, 1997, 4 : 40 - 46
[29] Effect of 5-aminolevulinic acid dose and estrogen on protoporphyrin IX concentrations in the rat uterus
Roy, BN
VanVugt, DA
Weagle, GE
Pottier, RH
Reid, RL
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 1997, 4 (01) : 40 - 46
[30] Light irradiation increases embryotoxicity of photodynamic therapy sensitizers (5-aminolevulinic acid and protoporphyrin IX) in chick embryos
Peterka, M
Klepácek, I
REPRODUCTIVE TOXICOLOGY, 2001, 15 (02) : 111 - 116

← 1 2 3 4 5 →