A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia

被引：0
|
作者：
Goemans, Bianca F. [1 ]
Zwaan, Christian M. [2 ]
Reinhardt, Dirk [3 ]
Gibson, Brenda E. S. [4 ]
Hahlen, K. [2 ,5 ]
Kaspers, Gert Jan L. [1 ,5 ]
机构：
[1] Vrije Univ Amsterdam Med Ctr, Dept Pediat Oncol Hematol, NL-1081 HV Amsterdam, Netherlands
[2] Erasmus MC Sophia Childrens Hosp, Dept Pediat Hematol Oncol, Rotterdam, Netherlands
[3] AML BFM Study Grp, Hannover, Germany
[4] UK Childhood Leukaemia Working Party, London, England
[5] Dutch Childhood Oncol Grp, The Hague, Netherlands
来源：
HAEMATOLOGICA | 2006年 / 91卷 / 11期
关键词：
liposomal daunorubicin; pediatric acute leukemia; drug sensitivity; cardiotoxicity;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differences between cytotoxicity of DNR and L-DNR.
引用
收藏
页码：1573 / 1574
页数：2
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