A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia

被引：0
|
作者：
Goemans, Bianca F. [1 ]
Zwaan, Christian M. [2 ]
Reinhardt, Dirk [3 ]
Gibson, Brenda E. S. [4 ]
Hahlen, K. [2 ,5 ]
Kaspers, Gert Jan L. [1 ,5 ]
机构：
[1] Vrije Univ Amsterdam Med Ctr, Dept Pediat Oncol Hematol, NL-1081 HV Amsterdam, Netherlands
[2] Erasmus MC Sophia Childrens Hosp, Dept Pediat Hematol Oncol, Rotterdam, Netherlands
[3] AML BFM Study Grp, Hannover, Germany
[4] UK Childhood Leukaemia Working Party, London, England
[5] Dutch Childhood Oncol Grp, The Hague, Netherlands
来源：
HAEMATOLOGICA | 2006年 / 91卷 / 11期
关键词：
liposomal daunorubicin; pediatric acute leukemia; drug sensitivity; cardiotoxicity;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differences between cytotoxicity of DNR and L-DNR.
引用
收藏
页码：1573 / 1574
页数：2
相关论文
共 50 条
  • [1] The use of liposomal daunorubicin (DaunoXome) in acute myeloid leukemia
    Fassas, A
    Anagnostopoulos, A
    LEUKEMIA & LYMPHOMA, 2005, 46 (06) : 795 - 802
  • [2] Liposomal daunorubicin (daunoxome) in the treatment of acute leukemia.
    Baccarani, M
    Michieli, M
    Russo, D
    Pierri, I
    Bonini, A
    Michelutti, A
    Pea, F
    Furlanut, M
    Fanin, R
    BLOOD, 1999, 94 (10) : 508A - 508A
  • [3] In vitro cytotoxicity of the LDE:daunorubicin complex in acute myelogenous leukemia blast cells
    Dorlhiac-Llacer, PE
    Marquezini, MV
    Toffoletto, O
    Carneiro, RCG
    Maranhao, RC
    Chamone, DAF
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2001, 34 (10) : 1257 - 1263
  • [4] Liposomal daunorubicin plasmatic and renal disposition in patients with acute leukemia
    Pea, F
    Russo, D
    Michieli, M
    Baraldo, M
    Ermacora, A
    Damiani, D
    Baccarani, M
    Furlanut, M
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2000, 46 (04) : 279 - 286
  • [5] Liposomal daunorubicin plasmatic and renal disposition in patients with acute leukemia
    Federico Pea
    Domenico Russo
    Mariagrazia Michieli
    Massimo Baraldo
    Anna Ermacora
    Daniela Damiani
    Michele Baccarani
    Mario Furlanut
    Cancer Chemotherapy and Pharmacology, 2000, 46 : 279 - 286
  • [6] Liposomal daunorubicin (Daunoxome) in the treatment of acute lymphocytic leukemia (ALL).
    Baccarani, M
    Russo, D
    Fanin, R
    Michieli, M
    BLOOD, 2000, 96 (11) : 720A - 720A
  • [7] Phase I study of liposomal daunorubicin in patients with acute leukemia
    Cortes, J
    O'Brien, S
    Estey, E
    Giles, F
    Keating, M
    Kantarjian, H
    INVESTIGATIONAL NEW DRUGS, 1999, 17 (01) : 81 - 87
  • [8] COMPARISON OF DAUNORUBICIN AND DAUNORUBICIN-DNA COMPLEX IN THE TREATMENT OF ACUTE NONLYMPHOBLASTIC LEUKEMIA
    PAUL, C
    BJORKHOLM, M
    CHRISTENSON, I
    ENGSTEDT, L
    GAHRTON, G
    HAST, R
    HOLM, G
    KILLANDER, A
    LANTZ, B
    LOCKNER, D
    LONNQVIST, B
    MELLSTEDT, H
    PALMBLAD, J
    PETERSON, C
    SIMONSSON, B
    STALFELT, AM
    UDEN, AM
    WADMAN, B
    OBERG, G
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1981, 6 (01) : 65 - 73
  • [9] Phase I study of liposomal daunorubicin in patients with acute leukemia
    Jorge Cortes
    Susan O'Brien
    Elihu Estey
    Francis Giles
    Michael Keating
    Hagop Kantarjian
    Investigational New Drugs, 1999, 17 : 81 - 87
  • [10] IN-VITRO CYTOTOXICITY OF MITOXANTRONE, DAUNORUBICIN AND DOXORUBICIN IN UNTREATED CHILDHOOD ACUTE-LEUKEMIA
    KASPERS, GJL
    VEERMAN, AJP
    PIETERS, R
    VANZANTWIJK, I
    KLUMPER, E
    HAHLEN, K
    DEWAAL, FC
    VANWERING, ER
    LEUKEMIA, 1994, 8 (01) : 24 - 29
12345