Synthesis, Crystal Structure and Anticancer Property of (Z)-N-(4-Bromo-5-ethoxy-3,5-dimethyl-furan-2(5H)-ylidene)-4-methylbenzenesulfonamide

被引：0

作者：

Zhang Shi-Jie ^{[1
]}

Hu Wei-Xiao ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310032, Zhejiang, Peoples R China

来源：

CHINESE JOURNAL OF STRUCTURAL CHEMISTRY | 2010年 / 29卷 / 08期

关键词：

synthesis; crystal structure; N-(4-bromo-5-ethoxy-3,5-dimethylfuran2(5H)-ylidene)-4-methylbenzenesulfonatnide; anticancer; EFFICIENT SYNTHESIS; AMINOHALOGENATION; 2,3-ALLENAMIDES; FACILE; ESTERS;

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The novel title compound (Z)-N-(4-bromo-5-ethoxy-3,5-dimethylfuran-2(5H)-ylidene)-4-methylbenzenesulfonamide 1 (C15H18BrNO4S) has been unexpectedly synthesized by the aminohalogenation reaction of ethyl 2-methylpenta-2,3-dienoate with TsNBr2, and characterized by mp, IR, H-1 NMR, Elms, ESIHRMS and single-crystal X-ray diffraction. It crystallizes in monoclinic, space group P2(1)/c with a = 11.714(5), b = 14.106(5), c = 10.402(4) angstrom, beta = 97.298(8)degrees, V = 1704.9(12) angstrom(3), M-r = 388.27, Z = 4, D-c = 1.513 g/cm(3), mu(MoK alpha) = 2.549 mm(-1), F(000) = 792, the final R = 0.033 and wR = 0.062 for 3098 observed reflections (I > 2 sigma(I)).

引用

页码：1275 / 1279

页数：5

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