Synthesis, Crystal Structure and Anticancer Property of (Z)-N-(4-Bromo-5-ethoxy-3,5-dimethyl-furan-2(5H)-ylidene)-4-methylbenzenesulfonamide

被引：0
|
作者：
Zhang Shi-Jie [1 ]
Hu Wei-Xiao [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310032, Zhejiang, Peoples R China
来源：
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY | 2010年 / 29卷 / 08期
关键词：
synthesis; crystal structure; N-(4-bromo-5-ethoxy-3,5-dimethylfuran2(5H)-ylidene)-4-methylbenzenesulfonatnide; anticancer; EFFICIENT SYNTHESIS; AMINOHALOGENATION; 2,3-ALLENAMIDES; FACILE; ESTERS;
D O I：
暂无
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The novel title compound (Z)-N-(4-bromo-5-ethoxy-3,5-dimethylfuran-2(5H)-ylidene)-4-methylbenzenesulfonamide 1 (C15H18BrNO4S) has been unexpectedly synthesized by the aminohalogenation reaction of ethyl 2-methylpenta-2,3-dienoate with TsNBr2, and characterized by mp, IR, H-1 NMR, Elms, ESIHRMS and single-crystal X-ray diffraction. It crystallizes in monoclinic, space group P2(1)/c with a = 11.714(5), b = 14.106(5), c = 10.402(4) angstrom, beta = 97.298(8)degrees, V = 1704.9(12) angstrom(3), M-r = 388.27, Z = 4, D-c = 1.513 g/cm(3), mu(MoK alpha) = 2.549 mm(-1), F(000) = 792, the final R = 0.033 and wR = 0.062 for 3098 observed reflections (I > 2 sigma(I)).
引用
收藏
页码：1275 / 1279
页数：5
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