Synthesis, Crystal Structure and Anticancer Property of (Z)-N-(4-Bromo-5-ethoxy-3,5-dimethyl-furan-2(5H)-ylidene)-4-methylbenzenesulfonamide

被引：0
|
作者：
Zhang Shi-Jie [1 ]
Hu Wei-Xiao [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310032, Zhejiang, Peoples R China
来源：
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY | 2010年 / 29卷 / 08期
关键词：
synthesis; crystal structure; N-(4-bromo-5-ethoxy-3,5-dimethylfuran2(5H)-ylidene)-4-methylbenzenesulfonatnide; anticancer; EFFICIENT SYNTHESIS; AMINOHALOGENATION; 2,3-ALLENAMIDES; FACILE; ESTERS;
D O I：
暂无
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The novel title compound (Z)-N-(4-bromo-5-ethoxy-3,5-dimethylfuran-2(5H)-ylidene)-4-methylbenzenesulfonamide 1 (C15H18BrNO4S) has been unexpectedly synthesized by the aminohalogenation reaction of ethyl 2-methylpenta-2,3-dienoate with TsNBr2, and characterized by mp, IR, H-1 NMR, Elms, ESIHRMS and single-crystal X-ray diffraction. It crystallizes in monoclinic, space group P2(1)/c with a = 11.714(5), b = 14.106(5), c = 10.402(4) angstrom, beta = 97.298(8)degrees, V = 1704.9(12) angstrom(3), M-r = 388.27, Z = 4, D-c = 1.513 g/cm(3), mu(MoK alpha) = 2.549 mm(-1), F(000) = 792, the final R = 0.033 and wR = 0.062 for 3098 observed reflections (I > 2 sigma(I)).
引用
收藏
页码：1275 / 1279
页数：5
相关论文
共 50 条
  • [1] Synthesis,Crystal Structure and Anticancer Property of (Z)-N-(4-Bromo-5-ethoxy-3,5-dimethyl-furan-2(5H)-ylidene)-4-methylbenzenesulfonamide
    张世杰
    胡惟孝
    结构化学, 2010, 29 (08) : 1275 - 1279
  • [2] N-(2-Allyl-4-ethoxy-2H-indazol-5-yl)-4-methylbenzenesulfonamide
    Chicha, Hakima
    Rakib, El Mostapha
    Bouissane, Latifa
    Viale, Maurizio
    Saadi, Mohamed
    El Ammari, Lahcen
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2014, 70 : O624 - +
  • [3] N-(3-Bromo-5-methyl-2-pyridyl)-4-methylbenzenesulfonamide
    Peng, Ming
    Luo, Youfu
    Chen, Lijuan
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O205 - U2866
  • [4] N-(2-Allyl-4-ethoxy-2H-indazol-5-yl)4-methylbenzenesulfonamide (vol 70, 0624, 2014)
    Chicha, Hakima
    Rakib, El Mostapha
    Bouissane, Latifa
    Viale, Maurizio
    Saadi, Mohamed
    El Ammari, Lahcen
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2014, 70 : E2 - E2
  • [5] N-(1-Allyl-3-chloro-4-ethoxy-1H-indazol-5-yl)-4-methylbenzenesulfonamide
    Chicha, Hakima
    Rakib, El Mostapha
    Bouissane, Latifa
    Saadi, Mohamed
    El Ammari, Lahcen
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2014, 70 : O653 - +
  • [6] Synthesis and Crystal Structures of Two Novel Complexes with N-[2-(5-Bromo-2-Hydroxybenzylideneamino)Ethyl]-4-Methylbenzenesulfonamide as Ligand
    Li, Shu-Ni
    Zhai, Quan-Guo
    Hu, Man-Cheng
    Jiang, Yu-Cheng
    JOURNAL OF CHEMICAL CRYSTALLOGRAPHY, 2011, 41 (01) : 12 - 16
  • [7] Synthesis and Crystal Structures of Two Novel Complexes with N-[2-(5-Bromo-2-Hydroxybenzylideneamino)Ethyl]-4-Methylbenzenesulfonamide as Ligand
    Shu-Ni Li
    Quan-Guo Zhai
    Man-Cheng Hu
    Yu-Cheng Jiang
    Journal of Chemical Crystallography, 2011, 41 : 12 - 16
  • [8] Synthesis and Structure of 5,5-Disubstituted N-[4-Methyl-3-phenylfuran-2(5H)-ylidene]-N′-phenylthioureas
    K. S. Avetisyan
    L. Kh. Galstyan
    R. A. Tamazyan
    A. G. Aivazyan
    Russian Journal of Organic Chemistry, 2018, 54 : 1109 - 1111
  • [9] N-(2-{[5-Bromo-2-(morpholin-4-yl)-pyrimidin-4-yl]sulfanyl}-4-methoxy-phenyl)-4-methylbenzenesulfonamide
    Kant, Rajni
    Gupta, Vivek K.
    Kapoor, Kamini
    Kumar, Mohan
    Mallesha, L.
    Sridhar, M. A.
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : 02590 - +
  • [10] Crystal structure of N-(2-tert-butyl-5-ethyl-4H-1,3-dioxin-4-yl)-4-methylbenzenesulfonamide,C17H25NO4S
    Wattenbach, C
    Flock, S
    Frauenrath, H
    Palme-König, R
    Müller, U
    ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2001, 216 (03): : 401 - 402
12345