A New Lignanamide from the Root of Lycium yunnanense Kuang and Its Antioxidant Activity

被引：18
|
作者：
Zheng, Xin-Heng [1 ]
Huang, Yuan-Peng [1 ]
Liang, Qiu-Ping [1 ]
Xu, Wei [1 ]
Lan, Ting [1 ]
Zhou, Guang-Xiong [1 ]
机构：
[1] Jinan Univ, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China
来源：
MOLECULES | 2018年 / 23卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Lycium yunnanense Kuang; lyciumamide K; ECD calculations; antioxidant activities; oxygen radical absorbance capacity (ORAC) assay; BARK; CHINENSE; GLYCOSIDES; BARBARUM; AMIDES; FRUITS; ASSAY;
D O I：
10.3390/molecules23040770
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new lignanamide (1), lyciumamide K, together with four known analogues (2-5), was isolated from the root of Lycium yunnanense Kuang. Based on HR-ESI-MS, NMR spectral data and quantum chemistry ECD calculations, the structure of this new compound was confirmed, including its absolute configuration. Evaluation of the antioxidant activity of compounds 1-5 in the oxygen radical absorption capacity (ORAC) assay showed that they all exhibited significant antioxidant activities. Particularly, compound 1 showed the best activity with ORAC values (U/mol) of 7.90 +/- 0.52. Thus, the new lignanamide may be a good source of bioavtive and protective compounds.
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页数：8
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