Microwave assisted synthesis of pyrazoline derivatives and their antiangiogenic and antioxidant activities

A series of pyrazolines were prepared both by conventional and microwave methods. Their, N-phenyl and acetyl derivatives were also prepared. The yields of these compounds by microwave method were found to be 70-85% for simple pyrazolines and 65-80% for N-phenyl substituted pyrazolines. Three compounds, II-4, III-6 and III-9 showed potent antiangiogenic activity by CAM assay. Weak or no antioxidant activity was observed for all the compounds by DPPH method.